Modification of an Analytical Procedure for Isocyanates to High Speed Liquid Chromatography

Details

• Personal Author:
  Ko-CY ; Ryan TR ; Vogt CR
• Description:
  The analysis of the industrial isocyanates using high speed liquid chromatography is shown and the advantages of this method over that of the thin layer chromatography counterpart are demonstrated. Minimum detectable limit of 2 nanograms was observed. Linearity up to 1,600 nanograms has been shown on the 25 centimeter Partisil 10 and 5 centimeter Partisil 5 columns. Reproducibility of repeated injections are within experimental errors. Samples are stable for at least 10 days. Column life and efficiency can be preserved by flushing the column daily and minimizing the amount of unreacted nitro reagent injected. Specific compounds that are qualitatively and quantitatively analyzed by the modified method are those generally found in working environments, i.e., 2,4-toluene- diisocyanate (584849); 2,6-toluene-diisocyanate, 4,4'- methylenebis(phenylisocyanate), 1,6-hexane-diisocyanate, and 1,3,5- tris(6-isocyanatohexyl)biuret. (Contract No. 210-75-0052) [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Hazardous Substances Isocyanates Occupational Health Safety
• Keywords:
  NIOSH-Contract; Contract-210-75-0052; Analytical-methods; Industrial-chemicals; Toxic-substances; Cyanates; Trace-analysis; Air-quality-measurement; Microanalysis
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Guidance
• Place as Subject:
  Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-93
• NIOSHTIC Number:
  nn:00072597
• NTIS Accession Number:
  PB-262675
• Citation:
  Environmental Trace Substance Research Center, University of Missouri, Columbia, Missouri 1976 Apr; :1-93
• CAS Registry Number:
  Biuret (CAS RN 108-19-0) ; Toluene 2,4-diisocyanate (CAS RN 584-84-9)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Source Full Name:
  Environmental Trace Substance Research Center, University of Missouri, Columbia, Missouri
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8aed16e4b892065a1ef7ef256733277fee46432391442498fd3c653c0b74c2354f8db6a56a99b0810742c0e044e0f41cb983dca03af6499c6ba24f10f433a2a4
• Download URL:
  https://stacks.cdc.gov/view/cdc/234057/cdc_234057_DS1.pdf
• File Type:
  [PDF - 3.84 MB ]