Editorial: Getting to the Heart of Developmental Toxicities

Details

• Personal Author:
  Bourque S ; Bowdridge EC ; Stapleton P ; Thompson J
• Description:
  The Developmental Origins of Health and Disease (DOHaD) hypothesis proposes that environmental exposures, particularly during gestation, can predispose offspring to chronic diseases and other poor health outcomes that persist into adulthood (Barker, 2007). During gestation the fetus is dependent upon the blood flow from the dam to provide the proper delivery of nutrients and oxygen for growth, as well as removal of fetal waste products. The source of maternal-fetal blood flow may be described as originating in the maternal heart and therefore any exposure that alters its function has the capability to disturb uteroplacental hemodynamics as well as fetal viability and growth, with potential lasting subsequent cardiometabolic consequences throughout life. Specifically, gestational environmental exposures can lead to cardiovascular disease, and/or complications from impacts on the fetal cardiovascular system such as renal or metabolic dysfunction. The interface between the mother and baby is the transient, but critically important, placenta. The relationships between maternal environmental influences, cardiovascular function, and fetal health is a budding field. This Research Topic contains three original research papers and a review that spans both rodents and humans highlighting the broad applicability of this topic and its importance to toxicology. [Description provided by NIOSH]
• Subjects:
  Environmental Exposure Occupational Health Pregnancy Safety Toxicology
• Keywords:
  Author Keywords: Reproduction Cardiovascular Development Developmental Disorders Development Origins Of Health And Disease DOHaD Environmental Exposure Placenta Prenatal Exposure
• ISSN:
  2673-3080
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; OSHA Region 2 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  5
• NIOSHTIC Number:
  nn:20067444
• Citation:
  Front Toxicol 2023 Jan; 5:1138470
• Contact Point Address:
  Elizabeth C. Bodridge, Department of Physiology, Pharmacology and Toxicology, West Virginia University School of Medicine, Morgantown, WV, United States
• Email:
  ebowdrid@hsc.wvu.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  West Virginia University
• Peer Reviewed:
  False
• Start Date:
  20220901
• Source Full Name:
  Frontiers in Toxicology
• End Date:
  20230831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ff79e9324e925ce13c2be5f9512b3efb35bdd61cbcc3164328e887565b2f2b1312b4c3c80d0d496098487206bc8842cb6867025bdcb0106a33a2fe310551ab02
• Download URL:
  https://stacks.cdc.gov/view/cdc/231461/cdc_231461_DS1.pdf
• File Type:
  [PDF - 512.62 KB ]