Development of Mechanical and Failure Properties in Sheep Cerebral Arteries

Details

• Personal Author:
  Albertine KH ; Converse MI ; Dahl MJ ; Monson KL ; Nye KS
• Description:
  Traumatic brain injury (TBI) is a devastating problem for people of all ages, but the nature of the response to such injury is often different in children than in adults. Cerebral vessel damage and dysfunction are common following TBI, but age-dependent, large-deformation vessel response has not been characterized. Our objective was to investigate the mechanical properties of cerebral arteries as a function of development. Sheep middle cerebral arteries from four age groups (fetal, newborn, juvenile, and adult) were subjected to biaxial loading around physiological conditions and then to failure in the axial direction. Results show little difference among age groups under physiological loading conditions, but response varied significantly with age in response to large axial deformation. Vessels from all age groups reached the same ultimate stretch level, but the amount of stress carried at a given level of stretch increased significantly with age through the developmental period (fetal to juvenile). Our results are the first to identify changes in cerebral vessel response to large deformations with age and may lead to new insights regarding differences in response to TBI with age. [Description provided by NIOSH]
• Subjects:
  Age Factors Animals Biomechanical Phenomena Blood Occupational Health Safety
• Keywords:
  Age Factors Animal Studies Author Keywords: Cerebral Artery Development Biomechanical Modeling Biomechanics Blood Vessel Mechanical Testing Blood Vessels Large Deformations TBI Traumatic Brain Injury Vessel Microstructure

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• ISSN:
  0090-6964
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 8 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  45
• Issue:
  4
• NIOSHTIC Number:
  nn:20067294
• Citation:
  Ann Biomed Eng 2017 Apr; 45(4):1101-1110
• Contact Point Address:
  Kenneth L. Monson, Department of Mechanical Engineering, University of Utah, 1495 E. 100 S., MEK 1550, Salt Lake City, UT 84112, USA
• Email:
  ken.monson@utah.edu
• Federal Fiscal Year:
  2017
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Annals of Biomedical Engineering
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d052f5c2249d3e0afde6403d91a8ccfd11bfcd22f66eb986f191e748a9f6de6b3af52ebc2f7dcd3dca339ed11515a87fa46dace4e3e342f7c468220e359dbf0c
• Download URL:
  https://stacks.cdc.gov/view/cdc/231394/cdc_231394_DS1.pdf
• File Type:
  [PDF - 1.18 MB ]