Cumulative Occupational Exposure to Inorganic Dust and Fumes and Invasive Pneumococcal Disease with Pneumonia

Details

• Personal Author:
  Blanc PD ; Murgia N ; Naidoo R ; Schiöler L ; Stockfelt L ; Torén, Kjell
• Description:
  Purpose: Occupational exposure to inorganic dust and fumes in the year preceding disease has been associated with increased pneumococcal pneumonia risk, but the impact of prior cumulative exposure has not been characterized. Methods: We studied 3184 cases of invasive pneumococcal disease with pneumonia. The case index date was the day the infection was diagnosed. We selected six controls for each case from the Swedish population registry; each control was assigned the index date of their corresponding case. We linked job histories to a job-exposure matrix to calculate a cumulative exposure index, intensity-years, by multiplying the duration (maximum 5 years) of each exposure with the level of exposure (0 for unexposed, 1 for low and 4 for high). We used conditional logistic analyses to estimate the odds ratio (OR) of invasive pneumococcal disease with pneumonia adjusted for comorbidities, educational level, income and other occupational exposures. Results: Taking other occupational exposures into account, greater than 5 intensity-years of exposure to silica dust or to fumes was each associated with increased odds for invasive pneumococcal disease with pneumonia (OR 2.53, 95% CI 1.49-4.32) and (OR 2.24, 95% CI 1.41-3.55), respectively. Five intensity-years or less of exposure to silica dust or fumes manifested lower odds (OR 1.45, 95% CI 1.20-1.76) and (OR 1.05, 95% CI 0.94-1.16), respectively. Conclusion: This study adds evidence that the risk of pneumococcal pneumonia increases with increasing cumulative exposure to dust and fumes, indicating the importance of cumulative exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Occupational Exposure Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Author Keywords: Pneumonia Bacterial Infections Case Control Dust Exposure Exposure Assessment Fumes Inorganic Dust JEM Job Exposure Matrix Occupational Exposure Pneumococci Pneumonia

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• ISSN:
  0340-0131
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  95
• Issue:
  8
• NIOSHTIC Number:
  nn:20067260
• Citation:
  Int Arch Occup Environ Health 2022 Oct; 95(8):1797-1804
• Contact Point Address:
  Kjell Torén, Occupational and Environmental Medicine, School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 414, 405 30, Gothenburg, Sweden
• Email:
  Kjell.Toren@amm.gu.se
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Archives of Occupational and Environmental Health
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:58d1aad060c43d3bf9a472c49b733cf1094efc97b29d8c6f3503535cb5668daff074736fce8a9bd947a37eb64f8a33eaf55da6fef97dbedfbbc5daa64e5624fb
• Download URL:
  https://stacks.cdc.gov/view/cdc/231373/cdc_231373_DS1.pdf
• File Type:
  [PDF - 691.14 KB ]