The Dependence of Particle Size on Cell Toxicity for Modern Mining Dust

Details

• Personal Author:
  Brindley S ; Brown JM ; Brune, Jürgen F. ; Chen Y-H ; Ma T ; Nguyen D ; Tsai CS-J ; Xia, T.
• Description:
  Progressive massive pulmonary fibrosis among coal miners has unexpectedly increased. It would likely due to the greater generation of smaller rock and coal particles produced by powerful equipment used in modern mines. There is limited understanding of the relationship between micro- or nanoparticles with pulmonary toxicity. This study aims to determine whether the size and chemical characteristics of typical coal-mining dust contribute to cellular toxicity. Size range, surface features, morphology, and elemental composition of coal and rock dust from modern mines were characterized. Human macrophages and bronchial tracheal epithelial cells were exposed to mining dust of three sub- micrometer and micrometer size ranges at varying concentrations, then assessed for cell viability and inflammatory cytokine expression. Coal had smaller hydrodynamic size (180-3000 nm) compared to rock (495-2160 nm) in their separated size fractions, more hydrophobicity, less surface charge, and consisted of more known toxic trace elements (Si, Pt, Fe, Al, Co). Larger particle size had a negative association with in-vitro toxicity in macrophages (p < 0.05). Fine particle fraction, approximately 200 nm for coal and 500 nm for rock particles, explicitly induced stronger inflammatory reactions than their coarser counterparts. Future work will study additional toxicity endpoints to further elucidate the molecular mechanism causing pulmonary toxicity and determine a dose-response curve. [Description provided by NIOSH]
• Subjects:
  Coal Coal Mining Dust Fibrosis Hazardous Substances Lung Diseases Mining Occupational Health Particulate Matter Respiratory Tract Diseases Safety

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• Keywords:
  Cell Biology Coal Dust Coal Miners Dusts Nanoparticles Particle Size Pulmonary System Disorders Toxins
• ISSN:
  2045-2322
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Colorado ; OSHA Region 8 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• NIOSHTIC Number:
  nn:20067243
• Citation:
  Sci Rep 2023 Mar; 13:5101
• Contact Point Address:
  Candace Su-Jung Tsai, Department of Environmental Health Sciences, Fielding School of Public Health, University of California, Los Angeles, 650 Charles E. Young Drive S., MC 177220, Los Angeles, CA 90095-1735
• Email:
  candacetsai@ucla.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Scientific Reports
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7cc0f5e0301fc7e7df10567ddbd9204bc0af92bbd0a044539d8b20cd76500dd0b8540d1789d257295055d6f38348845539d45585dd50e579db509036e1cba164
• Download URL:
  https://stacks.cdc.gov/view/cdc/231362/cdc_231362_DS1.pdf
• File Type:
  [PDF - 1.69 MB ]