Maternal Occupational Exposure to Chemicals and Child Cognitive Function

Details

• Personal Author:
  Casas M ; Delclos GL ; Gimeno Ruiz de Porras D ; Guxens M ; Ibarluzea JM ; Iñiguez C ; Ish J ; Lertxundi A ; Rebagliato M ; Swartz MD ; Symanski, Elaine ; Whitworth KW
• Description:
  Background: Limited data exist regarding child neurodevelopment in relation to maternal occupational exposure to endocrine-disrupting chemicals (EDCs). Methods: We included 1058 mother-child pairs from the INfancia y Medio Ambiente (INMA) project (2003-2008). Using a job-exposure matrix, exposure probability scores for ten EDC groups were assigned to each mother based on her longest held job during pregnancy. At the child's 5-year visit, the McCarthy Scales of Children's Abilities was administered, yielding the general cognitive index and scales for specific cognitive domains. We analyzed region-specific associations between EDC exposures and each outcome separately using adjusted linear regression and combined region-specific effect estimates using random-effects meta-analyses. Results: Approximately 24% of women were exposed to at least one EDC group, but exposure to most individual EDC groups was low (<5%). Maternal organic solvent exposure was associated with lower quantitative scores among children (-5.8 points, 95% confidence interval: -11.0, -0.5). Though statistically non-significant, exposures to polycyclic aromatic hydrocarbons, phthalates, alkylphenolic compounds, and miscellaneous chemicals were associated with poorer offspring performance for most or all cognitive domains. Conclusions: This study found limited evidence for a role of maternal occupational EDC exposures on child cognition. Further research is needed to better characterize exposures among pregnant workers. [Description provided by NIOSH]
• Subjects:
  Endocrine System Nervous System Occupational Exposure Occupational Health Pregnancy Safety
• Keywords:
  Children Cognitive Function Endocrine Disruptors Neurological System Occupational Exposure Prenatal Exposure
• ISSN:
  0031-3998
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  92
• Issue:
  4
• NIOSHTIC Number:
  nn:20066973
• Citation:
  Pediatr Res 2022 Oct; 92(4):1153-1160
• Contact Point Address:
  Kristina W. Whitworth, Department of Medicine, Baylor College of Medicine, Houston, TX, USA
• Email:
  kristina.whitwoth@bcm.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Pediatric Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6cd38563e6a4149f9991449c0871d4fb62839a7a3ccb9d790a71c21fce3d0de999c55e858ccaef38cd540fa661531468ed6da467975ae1ad6401c76073cb18ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/231230/cdc_231230_DS1.pdf
• File Type:
  [PDF - 642.11 KB ]