Lung Toxicity and Gene Expression Changes in Response to Whole-Body Inhalation Exposure to Cellulose Nanocrystal in Rats (Dataset)

Details

• Personal Author:
  Joseph P ; McKinney W ; Orandle M ; Roberts J ; Sager T ; Umbright C
• Description:
  Nanomaterials represent a new class of materials with numerous industrial applications. Considering the projected increase in the production and use of nanomaterials, a corresponding increase in occupational exposure to nanomaterials and their resulting adverse health effects should be anticipated among workers. There is substantial evidence in the literature, based on cell culture and animal studies, supporting the potential toxicity and detrimental health effects associated with exposure to nanomaterials. Intervention and/or prevention of adverse health effects associated with occupational exposure to toxic nanomaterials will be a major concern for health providers and regulatory and non-regulatory government agencies as the use of nanomaterials expand. A key element in the intervention and/or prevention of the adverse health effects associated with occupational exposure to toxic nanomaterials is a clear understanding of the molecular mechanisms underlying the pulmonary toxicity induced by nanomaterials. Due to its physicochemical and mechanical properties, nanocellulose has found many applications in manufactured goods in the paper and food industry, cosmetics, biomedicine, and pharmaceuticals. There is potential for human exposure to nanocellulose or products that contain nanocellulose both during the production and use of the materials that contain nanocellulose. The objectives of the current study were to determine lung toxicity potential of crystalline nanocellulose (CNC) and the molecular mechanisms underlying the toxicity. A rat inhalation exposure model was employed to determine the lung toxicity potential of CNC. Global gene expression profile in the lung and bioinformatic analysis of the gene expression data were conducted to determine the molecular mechanisms underlying the CNC-induced lung toxicity. [Description provided by NIOSH]
• Subjects:
  Animals Cellulose Lung Occupational Exposure Occupational Health Respiratory System Safety
• Keywords:
  Animal Studies Gene Expression Inhalation Studies Lung Irritants Lung Tissue Molecular Biology Nanocrystals Nanomaterials Occupational Exposure Toxic Effects
• DOI:
  https://doi.org/10.26616/NIOSHRD-1055-2023-0
• Publisher:
  National Institute for Occupational Safety and Health
• Document Type:
  Dataset
• Genre:
  Research Dataset
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20066893
• Citation:
  Morgantown, WV: U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Research Dataset RD-1055-2023-0, 2023 Feb; :dataset
• Contact Point Address:
  Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1000 Frederick Lane, Morgantown, WV 26508. Phone: 304.285.6240
• CAS Registry Number:
  Cellulose (CAS RN 9004-34-6)
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Lung toxicity and gene expression changes in response to whole-body inhalation exposure to cellulose nanocrystal in rats
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:805e0d4061b6aaa5b06245ec0cfe7da334c8748fd95c98a33fe7aeffe5b9ad3e9835fd59f119a3cf94d6eb5fe05e2cd48529346378cac0491723fac249134b2f
• Download URL:
  https://stacks.cdc.gov/view/cdc/231190/cdc_231190_DS1.pdf
• File Type:
  [PDF - 105.36 KB ]