Biomarkers of Heatstroke-Induced Organ Injury and Repair

Details

• Personal Author:
  Bouchama A ; Davis MS ; Schlader ZJ
• Description:
  Classic and exertional heatstroke cause acute injury and damage across numerous organ systems. Moreover, heatstroke survivors may sustain long-term neurological, cardiovascular and renal complications with a persistent risk of death. In this context, biomarkers, defined as biological samples obtained from heatstroke patients, are needed to detect early organ injury, and predict outcomes to develop novel organ preservation therapeutic strategies. This narrative review provides preliminary insights that will guide the development and future utilization of these biomarkers. To this end, we have identified numerous biomarkers of widespread heatstroke-associated cellular injury, tissue damage and repair (extracellular heat shock proteins 72 and 60, high mobility group box protein 1, histone H3, and interleukin-1a), and other organ-specific biomarkers including those related to the cardiovascular system (cardiac troponin I, endothelium-derived factors, circulation endothelial cells, adhesion molecules, thrombomodulin and von Willebrand factor antigen), the kidneys (plasma and urinary neutrophil gelatinase-associated lipocalin), the intestines (intestinal fatty acid-binding protein 2), the brain (serum S100beta and neuron-specific enolase) and skeletal muscle (creatine kinase, myoglobin). No specific biomarkers have been identified so far for liver or lung injury in heatstroke. Before translating the identified biomarkers into clinical practice, additional preclinical and clinical prospective studies are required to further understand their clinical utility, particularly for the biomarkers related to long-term post-heatstroke health outcomes. [Description provided by NIOSH]
• Subjects:
  Biomarkers Heat Exhaustion Heat Stress Disorders Hot Temperature Occupational Health Safety
• Keywords:
  Author Keywords: Biomarkers Biological Materials Cardiovascular System Cellular Effects Classic Heatstroke Exertional Heatstroke Heat Exposure Heat Stroke Hyperthermia Kidney Function Multiorgan Failure Organs Organ Systems Skeletal System

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• ISSN:
  0958-0670
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; Oklahoma ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  107
• Issue:
  10
• NIOSHTIC Number:
  nn:20066580
• Citation:
  Exp Physiol 2022 Oct; 107(10):1159-1171
• Contact Point Address:
  Zachary Schlader, Zachary J. Schlader, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, IN, USA
• Email:
  zschlade@indiana.edu
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Construction
• Performing Organization:
  Indiana University, Bloomington
• Peer Reviewed:
  True
• Start Date:
  20190901
• Source Full Name:
  Experimental Physiology
• End Date:
  20240831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9dc8c65f4872f4326e6c4f281147e66c95afa462686bcf951991783efe87d8247a71020deee3b1f90ad148f81075cf468e85b0c12e41207185e7100c95448fa1
• Download URL:
  https://stacks.cdc.gov/view/cdc/231129/cdc_231129_DS1.pdf
• File Type:
  [PDF - 1.94 MB ]