World Trade Center Dust Induces Nasal and Neurological Tissue Injury While Propagating Reduced Olfaction Capabilities and Increased Anxiety Behaviors

Details

• Personal Author:
  Chen, Lung-Chi ; Gandy, Sam ; Gordon,Terry ; Hernandez, Michelle ; Lippmann, Morton ; Vaughan, Joshua
• Description:
  Objective: Previous in vitro and in vivo World Trade Center particulate matter (WTCPM) exposure studies have provided evidence of exposure-driven oxidative/nitrative stress and inflammation on respiratory tract and aortic tissues. What remains to be fully understood are secondary organ impacts due to WTCPM exposure. This study was designed to test if WTC particle-induced nasal and neurologic tissue injury may result in unforeseen functional and behavioral outcomes. Material and Methods: WTCPM was intranasally administered in mice, evaluating genotypic, histopathologic, and olfaction latency endpoints. Results: WTCPM exposure was found to incite neurologic injury and olfaction latency in intranasally (IN) exposed mice. Single high-dose and repeat low-dose nasal cavity insults from WTCPM dust resulted in significant olfaction delays and enduring olfaction deficits. Anxiety-dependent behaviors also occurred in mice experiencing olfaction loss including significant body weight loss, increased incidence and time spent in hind stretch postures, as well as increased stationary time and decreased exploratory time. Additionally, WTCPM exposure resulted in increased whole brain wet/dry ratios and wet whole brain to body mass ratios that were correlated with exposure and increased exposure dose (p<0.05). Discussion: The potential molecular drivers of WTCPM-driven tissue injury and olfaction latency may be linked to oxidative/nitrative stress and inflammatory cascades in both upper respiratory nasal and brain tissues. Conclusion: Cumulatively, these data provide evidence of WTCPM exposure in relation to tissue damage related to oxidative stress-driven inflammation identified in the nasal cavity, propagated to olfactory bulb tissues and, potentially, over extended periods, to other CNS tissues. [Description provided by NIOSH]
• Subjects:
  Dust Emergency Responders Nose Occupational Health Particulate Matter Safety Sense Organs September 11 Terrorist Attacks
• Keywords:
  Animal Studies Author Keywords: World Trade Center Dust Central Nervous System Disaster Response Dust Exposure Dusts First Responders Intranasal Instillation Nasal Cavity Oxidative Stress Particulate Matter Exposure Particulates World Trade Center WTC

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  15 pdf pages
• Volume:
  34
• Issue:
  7
• NIOSHTIC Number:
  nn:20066974
• Citation:
  Inhal Toxicol 2022 Jul; 34(7-8):175-188
• Contact Point Address:
  Lung-Chi Chen, Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA
• Email:
  Lung-Chi.Chen@nyulangone.org
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a585f79bf2f37a1275952db88d89872546a4f88a2a737814e175e5807503c58455d07f6d967f31a93de4f727b71a3ceff71345ee38c5a0da8d75a9d0b983f867
• Download URL:
  https://stacks.cdc.gov/view/cdc/230827/cdc_230827_DS1.pdf
• File Type:
  [PDF - 2.13 MB ]