The Association of Post-Traumatic Stress Disorder with Glomerular Filtration Rate Decline

Details

• Personal Author:
  Cohen, Beth E. ; Hajagos, Janos ; Hou, Wei ; Koraishy, Farrukh M. ; Robinson-Cohen, Cassianne ; Scherrer, Jeffery F. ; Whooley, Mary
• Description:
  While major depression is known to be associated with glomerular filtration rate (GFR) decline, there is a lack of data on the association of other mental illnesses like posttraumatic stress disorder (PTSD) with kidney disease. In 640 adult participants of the Heart and Soul Study (mean baseline age of 66.2 years) with a high prevalence cardiovascular disease, hypertension and diabetes, we examined the association of PTSD with GFR decline over a 5-year follow-up. We observed a significantly greater estimated (e) GFR decline over time in those with PTSD compared to those without (2.97 vs. 2.11 ml/min/1.73 m2/year; p = .022). PTSD was associated with 91% (95% CI 12%-225%) higher odds of 'rapid' versus 'mild' (>3.0 vs. <3.0 ml/min/1.73 m2/per year) eGFR decline. These associations remained consistent despite controlling for demographics, medical comorbidities, other mental disorders and psychiatric medications. In conclusion, our study provides evidence that PTSD is independently associated with GFR decline in middle-aged adults with a high comorbidity burden. This association needs to be examined in larger cohorts with longer follow-ups. [Description provided by NIOSH]
• Subjects:
  Epidemiology Mental Health Nervous System Occupational Health Safety Stress Disorders, Post-Traumatic Urogenital System
• Keywords:
  Author Keywords: Chronic Kidney Disease Glomerular Filtration Rate Kidney Function Kidneys Longitudinal Study Mental Health Nephrological Disorders Post-traumatic Stress Disorder PTSD
• ISSN:
  1320-5358
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  6 pdf pages
• Volume:
  28
• NIOSHTIC Number:
  nn:20066869
• Citation:
  Nephrology 2023 Mar; 28(3):181-186
• Contact Point Address:
  Farrukh M. Koraishy, Department of Medicine/Nephrology, Stony Brook University, 100 Nicolls Road, HSCT16-080 E, Stony Brook, NY, USA
• Email:
  farrukh.koraishy@stonybrookmedicine.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  State University of New York Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20210701
• Source Full Name:
  Nephrology
• End Date:
  20230630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4a8199e05119f94c0fed8369244e1391e5bcbc39bbc9a8ac2ff9fe7b4a324b5ecd290beb128c7775ace1582de2e3eb10ea922c7746b1314ed201e4c7d05ea13b
• Download URL:
  https://stacks.cdc.gov/view/cdc/230824/cdc_230824_DS1.pdf
• File Type:
  [PDF - 808.92 KB ]