Gadolinium Deposition in the Rat Brain Measured with Quantitative MRI Versus Elemental Mass Spectrometry

Details

• Personal Author:
  Anderson, Stephan W. ; Babcock, Katharine J. ; Franz, Erich S. ; Goldstein, Lee E. ; Guermazi, Ali ; Hua, Ning ; Jara, Hernan ; Liu, Xiuping ; Lupoli, Nicola ; Minaeva, Olga ; Moncaster, Juliet A. ; Soto, Jorge A. ; Tripodis, Yorghos
• Description:
  Abstract: Gadolinium retention in the brain measured with MRI longitudinal relaxation rate mapping and laser ablation inductively coupled plasma mass spectrometry yielded different results, indicating that some forms of retained gadolinium may escape detection with MRI. Background: T1-weighted MRI and quantitative longitudinal relaxation rate (R1) mapping have been used to evaluate gadolinium retention in the brain after gadolinium-based contrast agent (GBCA) administration. Whether MRI measures accurately reflect gadolinium regional distribution and concentration in the brain remains unclear. Purpose: To compare gadolinium retention in rat forebrain measured with in vivo quantitative MRI R1 and ex vivo laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) mapping after gadobenate, gadopentetate, gadodiamide, or gadobutrol administration. Materials and Methods: Adult female Sprague-Dawley rats were randomly assigned to one of five groups (eight per group) and administered gadobenate, gadopentetate, gadodiamide, gadobutrol (2.4 mmol/kg per week for 5 weeks), or saline (4.8 mL/kg per week for 5 weeks). MRI R1 mapping was performed at baseline and 1 week after the final injection to determine R1 and deltaR1. Postmortem brains from the same rats were analyzed with LA-ICP-MS elemental mapping to determine regional gadolinium concentrations. Student t tests were performed to compare results between GBCA and saline groups. Results: Rats that were administered gadobenate showed gadolinium-related MRI deltaR1 in 39.5% of brain volume (deltaR1 = 0.087 second-1 +/- 0.051); gadopentetate, 20.6% (deltaR1 = 0.069 second-1 +/- 0.018); gadodiamide, 5.4% (deltaR1 = 0.055 second-1 +/- 0.019); and gadobutrol, 2.2% (deltaR1 = 0.052 second-1 +/- 0.041). Agent-specific gadolinium-related deltaR1 was detected in multiple forebrain regions (neocortex, hippocampus, dentate gyrus, thalamus, and caudate-putamen) in rats treated with gadobenate or gadopentetate, whereas rats treated with gadodiamide showed gadolinium-related deltaR1 in caudate-putamen. By contrast, LA-ICP-MS elemental mapping showed a similar regional distribution pattern of heterogeneous retained gadolinium in the forebrain of rats treated with gadobenate, gadopentetate, or gadodiamide, with the average gadolinium concentration of 0.45 µg · g-1 +/- 0.07, 0.50 µg · g-1 +/- 0.10, and 0.60 µg · g-1 +/- 0.11, respectively. Low levels (0.01 µg · g-1 +/- 0.00) of retained gadolinium were detected in the forebrain of gadobutrol-treated rats. Conclusion: Differences in in vivo MRI longitudinal relaxation rate versus ex vivo elemental mass spectrometry measures of retained gadolinium in rat forebrains suggest that some forms of retained gadolinium may escape detection with MRI. [Description provided by NIOSH]
• Subjects:
  Animals Occupational Health Radiation Safety
• Keywords:
  Animal Studies Imaging Techniques In Vivo Studies Magnetic Resonance Imaging Mass Spectrometry MRI Radiology
• ISSN:
  0033-8419
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  8 pdf pages
• Volume:
  306
• NIOSHTIC Number:
  nn:20067166
• Citation:
  Radiology 2023 Jan; 306(1):244-251
• Contact Point Address:
  Lee E. Goldstein, Department of Radiology, Boston University School of Medicine, 670 Albany St, 4th Floor, Boston, MA 02118
• Email:
  lgold@bu.edu
• CAS Registry Number:
  Gadolinium (CAS RN 7440-54-2)
• Federal Fiscal Year:
  2023
• Performing Organization:
  Boston University Medical Campus
• Peer Reviewed:
  True
• Start Date:
  20180930
• Source Full Name:
  Radiology
• End Date:
  20220929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a4f7768915791c3e4471f96e6a81ac051a2a25aeb9d3c10d6a485cf8d451d3cebacb5872c0e995b4096935e4454e8b8151d85924c0be1529615ec8340692ea4c
• Download URL:
  https://stacks.cdc.gov/view/cdc/230788/cdc_230788_DS1.pdf
• File Type:
  [PDF - 1.05 MB ]