Polypharmacy and Frailty Among World Trade Center General Responders

Details

• Personal Author:
  Bello G ; Hung W ; Ko F ; Lucchini R ; Ornstein K ; Sabra A ; Thanik E
• Description:
  Polypharmacy in older adults is associated with increased risk of adverse events such as falls, adverse drug reactions and functional decline. WTC responders suffer from conditions related to WTC exposure and are at higher risk of polypharmacy. We examined patterns of medication use among WTC general responders aged 50 and over who had at least one visit from 2017 to 2019 (n=7,679); 56.1% took 5+ medications and 22.5% took 10+ medications. Factors associated with polypharmacy (taking 5+ medications) include age (OR 1.08, p<0.001), female sex (OR 1.33, p<0.001), obesity (1.90, p<0.001), fair/poor self-rated health (OR 1.32, p<0.001) and limitations on performing moderate activity (OR 1.52, p<0.001). Frailty, as measured by the deficit count in the Clinical Frailty Index, is associated with polypharmacy after adjusting for other covariates (OR 1.23, p<0.001). Addressing polypharmacy by improving medication use may yield health benefits for this rapidly aging population at risk for adverse outcomes. [Description provided by NIOSH]
• Subjects:
  Aging Biopharmaceutics Emergency Responders Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  First Responders Pharmaceuticals Prescription Drugs Rescue Workers World Trade Center WTC
• ISSN:
  2399-5300
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Abstract or Summary
• Place as Subject:
  Florida ; Maryland ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  47
• Volume:
  6
• NIOSHTIC Number:
  nn:20068356
• Citation:
  Innov Aging 2022 Nov; 6(Suppl 1):47
• Federal Fiscal Year:
  2023
• Performing Organization:
  Icahn School of Medicine at Mount Sinai, New York
• Peer Reviewed:
  False
• Start Date:
  20200701
• Source Full Name:
  Innovation in Aging
• Supplement:
  1
• End Date:
  20210630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d7fc864bc44167b4831362359a9c6a789fc0ae527d55a352df8a049d61c3b223d78443798ba1f4aed964d2bcdc30f063ae39c0ed1aeb375d055de941e07e06b3
• Download URL:
  https://stacks.cdc.gov/view/cdc/230520/cdc_230520_DS1.pdf
• File Type:
  [PDF - 81.56 KB ]