The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders

Details

• Personal Author:
  Christiani D ; Gao S ; Guasch-Ferre M ; Hu F ; Hutchinson JM ; Lin X ; Quick C ; Su L ; Zhuo Z
• Description:
  Introduction: Human metabolism and inflammation are closely related modulators of homeostasis and immunity. Metabolic profiling is a useful tool to understand the association between metabolism and inflammation at a systemic level. Objective: To investigate the longitudinal associations between the concentration of plasma metabolites and biomarkers related to inflammation and oxidative stress. Methods: We conducted a repeated cross-sectional analysis consisting of 8 short-term panels that included 88 healthy adult male welders in Massachusetts, USA. In each panel, we collected 1- 6 repeated measurements of blood and urine. We used a human vascular injury panel assay and custom cytokine/chemokine assay to quantify inflammatory biomarker plasma levels, liquid chromatography-mass spectrometry to quantify the concentrations of 665 plasma metabolites, and a competitive enzyme-linked immunoassay to quantify urinary 8-OHdG and 8-isoprostane levels. We used linear mixed effects models to estimate the longitudinal association between each inflammatory and oxidative stress biomarker and each metabolite. Results: At a 5% FDR threshold, we detected ≥ 1metabolite association for 8 unique inflammatory and oxidative stress biomarkers: urinary 8-isoprostane, plasma C-reactive protein (CRP), serum amyloid A (SAA), intercellular adhesion molecule 1, circulating vascular cell adhesion molecule-1, interleukin 8 (IL-8), interleukin 10 (IL-10) and vascular endothelial growth factor. Specifically, 3 metabolites in the androgenic steroids pathway were negatively associated with SAA; 3 dihydrosphingomyelins metabolites were positively associated with 1 or more of CRP, SAA, IL-8 and IL-10; 4 metabolites in acyl choline metabolism pathways were negatively associated with IL-8; 7 lysophospholipid metabolites were negatively associated with 1 or more of CRP, SAA and IL-8; 4 sphingomyelins were positively associated with CRP and/or SAA; and 10 metabolites in the xanthine pathway were positively associated with urinary 8-isoprostane. Conclusion: We found that metabolites in phospholipid groups had strong associations with multiple inflammatory biomarkers, especially CRP, SAA and IL-8. The mechanism of these associations warrants further investigation. [Description provided by NIOSH]
• Subjects:
  Biomarkers Energy Metabolism Occupational Health Safety Welding
• Keywords:
  Author Keywords: Metabolism Chronic Inflammation Cross Sectional Studies Inflammation Longitudinal Study Metabolism Metabolites Metabolomics Metals Occupational Health Oxidative Stress Particulates Phospholipids Welders

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• ISSN:
  1178-7031
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  14
• NIOSHTIC Number:
  nn:20068072
• Citation:
  J Inflamm Res 2021 Jun; 14:2825-2839
• Contact Point Address:
  David Christiani, Environmental Health, Harvard University T H Chan School of Public Health, Boston, MA, 02115, USA
• Email:
  dchris@hsph.harvard.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Inflammation Research
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:84dfc5c4e77ae8f5a04fce47c057bfaf0deae4ab0982cd6e79d02ada9bab4a1c75a648b3f6391a8f32a91826579f2ad0af12ef0db88d502cc7747f69bf4232d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/230291/cdc_230291_DS1.pdf
• File Type:
  [PDF - 2.32 MB ]