Breast Cancer Characteristics in the Population of Survivors Participating in the World Trade Center Environmental Health Center Program 2002–2019

Details

• Personal Author:
  Addessi A ; Arslan AA ; Durmus N ; Pehlivan S ; Reibman J ; Schnabel F ; Shao Y ; Zhang Y
• Description:
  The destruction of World Trade Center on 11 September 2001 exposed local community members to a complex mixture of known carcinogens and potentially carcinogenic substances. To date, breast cancer has not been characterized in detail in the WTC-exposed civilian populations. The cancer characteristics of breast cancer patients were derived from the newly developed Pan-Cancer Database at the WTC Environmental Health Center (WTC EHC). We used the Surveillance, Epidemiology, and End Results (SEER) Program breast cancer data as a reference source. Between May 2002 and 31 December 2019, 2840 persons were diagnosed with any type of cancer at the WTC EHC, including 601 patients with a primary breast cancer diagnosis (592 women and 9 men). There was a higher proportion of grade 3 (poorly differentiated) tumors (34%) among the WTC EHC female breast cancers compared to that of the SEER-18 data (25%). Compared to that of the SEER data, female breast cancers in the WTC EHC had a lower proportion of luminal A (88% and 65%, respectively), higher proportion of luminal B (13% and 15%, respectively), and HER-2-enriched (5.5% and 7%, respectively) subtypes. These findings suggest considerable differences in the breast cancer characteristics and distribution of breast cancer intrinsic subtypes in the WTC-exposed civilian population compared to that of the general population. This is important because of the known effect of molecular subtypes on breast cancer prognosis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Dust Environmental Exposure Epidemiology Neoplasms Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  9/11 Author Keywords: Breast Cancer Breast Cancer Cancer Rates Dust Exposure Environmental Exposure Exposure Assessment Surveillance Programs World Trade Center WTC
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  14
• NIOSHTIC Number:
  nn:20068069
• Citation:
  Int J Environ Res Public Health 2021 Jul; 18(14):7555
• Contact Point Address:
  Alan A. Arslan, Department of Obstetrics and Gynecology, New York University Langone Health, New York, NY 10016, USA
• Email:
  arslan@nyumc.org
• Federal Fiscal Year:
  2021
• Performing Organization:
  NYC Health + Hospitals (H+H): NYC H+H Data Center
• Peer Reviewed:
  True
• Start Date:
  20170401
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20210331
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:82f902d371e74e9d13ef639b60194caa64210651dd2d37abc422115d6125718b4f7c139a312de491caf3fd578ad132f4620af93aed5f238a15207294d3ea93f6
• Download URL:
  https://stacks.cdc.gov/view/cdc/230288/cdc_230288_DS1.pdf
• File Type:
  [PDF - 330.01 KB ]