Unraveling the Effect of Collagen Damage on Bone Fracture Using In Situ Synchrotron Microtomography with Deep Learning

Details

• Personal Author:
  Acevedo C ; Barnard HS ; Obata Y ; Parkinson DY ; Pelt DM ; Rosenberg JL ; Sieverts M ; Woolley W
• Description:
  When studying bone fragility diseases, it is difficult to identify which factors reduce bone's resistance to fracture because these diseases alter bone at many length scales. Here, we investigate the contribution of nanoscale collagen behavior on macroscale toughness and microscale toughening mechanisms using a bovine heat-treatment fragility model. This model is assessed by developing an in situ toughness testing technique for synchrotron radiation micro-computed tomography to study the evolution of microscale crack growth in 3D. Low-dose imaging is employed with deep learning to denoise images while maintaining bone's innate mechanical properties. We show that collagen damage significantly reduces macroscale toughness and post-yield properties. We also find that bone samples with a compromised collagen network have reduced amounts of crack deflection, the main microscale mechanism of fracture resistance. This research demonstrates that collagen damage at the nanoscale adversely affects bone's toughening mechanisms at the microscale and reduces the overall toughness of bone. [Description provided by NIOSH]
• Subjects:
  Occupational Health Safety
• Keywords:
  Biomechanical Engineering Biomedical Engineering Bone Disorders Bone Structure Collagen Fibrils Imaging Techniques Nanotechnology
• ISSN:
  2662-4443
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 8 ; OSHA Region 9 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  78
• Volume:
  3
• NIOSHTIC Number:
  nn:20067815
• Citation:
  Commun Mater 2022 Oct; 3:78
• Contact Point Address:
  Claire Acevedo, Department of Mechanical Engineering, University of Utah, 1495 E 100 S, Salt Lake City, UT, 84112, USA
• Email:
  claire.acevedo@utah.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Utah
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Communications Materials
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cc8273f18e77be47732f39eb60841c050a7c35b68b8cf7a957f6e1fef71869a82c105c2407aa655fc06709a5807d6478defa6b7c956057fc8eeb913a91c3b53d
• Download URL:
  https://stacks.cdc.gov/view/cdc/230071/cdc_230071_DS1.pdf
• File Type:
  [PDF - 6.23 MB ]