Toxicogenomics of Multi-Walled Carbon Nanotubes

Details

• Personal Author:
  Joseph P
• Description:
  Advanced materials having at least one dimension in the nanoscale (1-100 nm) and manufactured for specific purposes are considered as engineered nanomaterials (ENMs). ENMs exhibit many unique properties, intended for superior performance compared with conventional materials, such as nano size, light weight, and increase in surface area, tensile strength, rigidity, and stability. Additionally, ENMs may exhibit superior electromagnetic, catalytic, thermal, and pharmacokinetic properties, facilitating their use in many commercial, industrial, and medical applications. Many of the same desirable properties of ENMs that enable their use in such applications have also raised concern from a human health and safety standpoint. For example, due to their light weight, ENMs can be easily aerosolized with potential for inhalation exposure among workers who are engaged in the manufacture of ENMs or ENM-containing products. Similarly, the size of the ENMs in the nanoscale may enable their entry into deep anatomical areas in the lungs and interaction with cellular components to result in biological activity that may be quantitatively and/or qualitatively distinct from their large-sized counterparts of similar chemical composition. Despite the limited epidemiological data, results obtained from many animal studies have demonstrated lung toxicity caused by exposure to ENMs. Many such studies were conducted using multi-walled carbon nanotubes (MWCNT) whose potential to result in damage, inflammation, oxidative stress, fibrosis, genotoxicity, mesothelioma, and cancer in the lungs has been demonstrated. Toxicogenomic, in particular transcriptomic, studies conducted recently have identified the genes whose expressions were altered in response to pulmonary exposure to MWCNT. Bioinformatic analysis of the transcriptomic data has provided significant insight into the molecular mechanisms underlying the pulmonary toxicity of MWCNT. Our current understanding regarding the pulmonary toxicity of MWCNT and the molecular mechanisms underlying the toxicity are presented in this chapter. [Description provided by NIOSH]
• Subjects:
  Aerosols Epidemiology Fibrosis Lung Lung Diseases Neoplasms Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Genomics Inhalation Lung Cancer Mesothelioma Multi-walled Carbon Nanotubes MWCNT Nanomaterials Oxidative Stress
• ISBN:
  9781119896227
• Publisher:
  Wiley
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  187-215
• NIOSHTIC Number:
  nn:20067778
• Citation:
  Impact of engineered nanomaterials in genomics and epigenomics. Sahu SC, ed. Hoboken, NJ: Wiley, 2023 May; :187-215
• Contact Point Address:
  Pius Joseph, Molecular Carcinogenesis Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health (NIOSH), 1095 Willowdale Road, Morgantown, WV
• CAS Registry Number:
  Carbon nanotubes (CAS RN 308068-56-6)
• Editor(s):
  Sahu SC
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Construction
• Peer Reviewed:
  False
• Source Full Name:
  Impact of engineered nanomaterials in genomics and epigenomics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:05a7e435527d8e5529bae253e1086841b944c8f51121e12a0d608fd4c00af8548a4d94fa15a24d7c256bae1eb232b03c514f6a404fd4444807cc990d867f0708
• Download URL:
  https://stacks.cdc.gov/view/cdc/230038/cdc_230038_DS1.pdf
• File Type:
  [PDF - 1008.76 KB ]