Associations Between Air Pollution Exposure and Blood Pressure During Pregnancy Among PRINCESA Cohort Participants

Details

• Personal Author:
  Buxton MA ; Castillo-Castrejon M ; Godines-Enriquez MS ; Gronlund CJ ; Heydarzadeh S ; O'Neill MS ; Vadillo-Ortega F
• Description:
  High blood pressure (BP) is a risk factor for hypertensive disease during pregnancy. Exposure to multiple toxic air pollutants can affect BP in pregnancy but has been rarely studied. We evaluated trimester-specific associations between air pollution exposure and systolic (SBP) and diastolic BP (DBP). Ozone (O3), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and particulate matter less than 10 and 2.5 µm in aerodynamic diameter (PM10, PM2.5) in the Pregnancy Research on Inflammation, Nutrition, & City Environment: Systematic Analyses (PRINCESA) study. Multipollutant generalized linear regression models with each pollutant and O3 were fit. Due to nonlinear pollution/BP associations, results are presented for "below the median" or "above the median", where the beta estimate is the change in BP at a pollutant's median versus BP at the pollutant's minimum or maximum, respectively. Associations varied across trimesters and pollutants, and deleterious associations (higher blood pressure with higher pollution) were found only at pollutant values below the median: for SBP with NO2 in the second and third trimesters, and PM2.5 during the third trimester, and for DBP, PM2.5, and NO2 in the second and third trimesters. Findings suggest that minimizing prenatal exposure to air pollution may reduce the risks of changes in BP. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Carbon Monoxide Cardiovascular Diseases Cardiovascular System Occupational Health Ozone Particulate Matter Pregnancy Safety Women
• Keywords:
  Air Pollutants Author Keywords: Ambient Air Pollution Blood Pressure Carbon Monoxide Cardiovascular Health Risks Hypertension Maternal Health Nitrogen Dioxides Particulates Prenatal Exposure Sulfur Dioxide Systolic Pressure Trimester-specific Exposure

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• ISSN:
  2305-6304
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; Oklahoma ; OSHA Region 5 ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  11
• Issue:
  5
• NIOSHTIC Number:
  nn:20067670
• Citation:
  Toxics 2023 May; 11(5):424
• Contact Point Address:
  Miatta A. Buxton, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109
• Email:
  mabuxton@umich.edu
• Federal Fiscal Year:
  2023
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Toxics
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:312dc8261e7a99cee92b197b6d57bafca6dff052fed4ce5e13ea9bcb58d3ebbdf1a9a12cd94a9e9677ba6e244eb17ef06f10250f15ba0867101e600d62003daf
• Download URL:
  https://stacks.cdc.gov/view/cdc/229938/cdc_229938_DS1.pdf
• File Type:
  [PDF - 528.89 KB ]