The Association of Forced Expiratory Volume in One Second with Occupational Exposures in a Longitudinal Study of Adults in a Rural Community in Iowa

Details

• Personal Author:
  Cox-Ganser, Jean M. ; Doney BC ; Henneberger, Paul K. ; Humann MJ ; Kelly KM ; Liang X ; Rollins SM
• Description:
  Purpose: The Keokuk County Rural Health Study (KCRHS) is a longitudinal population-based study conducted in rural Iowa. A prior analysis of enrollment data identified an association of airflow obstruction with occupational exposures only among cigarette smokers. The current study used spirometry data from all three rounds to investigate whether level of forced expiratory volume in one second (FEV1) and longitudinal change in FEV1 were associated with occupational vapor-gas, dust, and fumes (VGDF) exposures, and whether these associations were modified by smoking. Methods: This study sample comprised 1071 adult KCRHS participants with longitudinal data. A job-exposure matrix (JEM) was applied to participants' lifetime work histories to assign exposures to occupational VGDF. Mixed regression models of pre-bronchodilator FEV1 (millimeters, ml) were fit to test for associations with occupational exposures while adjusting for potential confounders. Results: Mineral dust had the most consistent association with change in FEV1, including ever/never ( - 6.3 ml/year) and nearly every level of duration, intensity, and cumulative exposure. Because 92% of participants with mineral dust also had organic dust exposure, the results for mineral dust may be due to a combination of the two. An association of FEV1 level with fumes was observed for high intensity ( - 91.4 ml) among all participants, and limited to cigarette smokers with results of - 104.6 ml ever/never exposed, - 170.3 ml high duration, and - 172.4 ml high cumulative. Conclusion: The current findings suggest that mineral dust, possibly in combination with organic dust, and fumes exposure, especially among cigarette smokers, were risk factors for adverse FEV1 results. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Occupational Exposure Occupational Health Respiratory Function Tests Respiratory System Safety Solvents
• Keywords:
  Airflow Airway Obstruction Author Keywords: Job-exposure Matrix Cigarette Smoke Fumes Gases Lifetime Work History Longitudinal Study Mineral Dusts Obstructive Pulmonary Disease Occupational Exposure Organic Dusts Rural Adults Spirometry Vapors

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• ISSN:
  0340-0131
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; OSHA Region 3 ; OSHA Region 7 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  96
• Issue:
  6
• NIOSHTIC Number:
  nn:20067655
• Citation:
  Int Arch Occup Environ Health 2023 Aug; 96(6):919-930
• Contact Point Address:
  Paul K. Henneberger, Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1000 Frederick Lane, MS H2900, Morgantown, WV 26508
• Email:
  pkh0@cdc.gov
• Federal Fiscal Year:
  2023
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Iowa, Iowa City
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  International Archives of Occupational and Environmental Health
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a664253fff7efda061775f8590a27e3b35994cafdbd821258a153c0f5b0f73db78cc6801f50aa2eb49482204a001cfc56ee62e7dfcc600ddbb4bc7aa1f590d0
• Download URL:
  https://stacks.cdc.gov/view/cdc/229925/cdc_229925_DS1.pdf
• File Type:
  [PDF - 693.34 KB ]