An In Vivo Platform for Tumor Biomarker Assessment

Servais, Elliot L.; Suzuki, Kei; Colovos, Christos; Rodriguez, Luis; Sima, Camelia; Fleisher, Martin; Rusch, Valerie W.; Sadelain, Michel; Adusumilli, Prasad S.

doi:10.1371/journal.pone.0026722

i

An In Vivo Platform for Tumor Biomarker Assessment

Supporting Files

Oct 26 2011
By Servais, Elliot L. ; Suzuki, Kei ; Colovos, Christos ; ...

File Language:

English

Details

Alternative Title:

PLoS One
Personal Author:

Servais, Elliot L. ; Suzuki, Kei ; Colovos, Christos ; Rodriguez, Luis ; Sima, Camelia ; Fleisher, Martin ; Rusch, Valerie W. ; Sadelain, Michel ; Adusumilli, Prasad S.
Description:

Tumor biomarkers provide a quantitative tool for following tumor progression and response to therapy. However, investigations of clinically useful tumor biomarkers are time-consuming, costly, and limited by patient and tumor heterogeneity. In addition, assessment of biomarkers as indicators of therapy response is confounded by the concomitant use of multiple therapeutic interventions. Herein we report our use of a clinically relevant orthotopic animal model of malignant pleural mesothelioma for investigating tumor biomarkers. Utilizing multi-modality imaging with correlative histopathology, we demonstrate the utility and accuracy of the mouse model in investigating tumor biomarkers--serum soluble mesothelin-related peptide (SMRP) and osteopontin (OPN). This model revealed percentage change in SMRP level to be an accurate biomarker of tumor progression and therapeutic response--a finding consistent with recent clinical studies. This in vivo platform demonstrates the advantages of a validated mouse model for the timely and cost-effective acceleration of human biomarker translational research.
Subjects:

Animals Diagnostic Imaging GPI-Linked Proteins Mesothelioma Methods Mice Models, Animal Osteopontin Pleural Neoplasms Tumor Markers, Biological
Source:

PLoS One. 2011; 6(10).
Pubmed ID:

22046338
Pubmed Central ID:

PMC3202552
Document Type:

Journal Article
Funding:

PR101053/PR/OCPHP CDC HHS/United States ; U54CA137788/U54CA132378/CA/NCI NIH HHS/United States
Volume:

6
Issue:

10
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:503a62193440e8346158e6629ca85dac6a6dd9a83c9284be49563e384b929a9a
Download URL:

https://stacks.cdc.gov/view/cdc/22796/cdc_22796_DS1.pdf
File Type:

[PDF - 1.86 MB ]

File Language:

English

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