CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women

Azrak, Sami; Ayyasamy, Vanniarajan; Zirpoli, Gary; Ambrosone, Christine; Bandera, Elisa V.; Bovbjerg, Dana H.; Jandorf, Lina; Ciupak, Gregory; Davis, Warren; Pawlish, Karen S.; Liang, Ping; Singh, Keshav

doi:10.1371/journal.pone.0029548

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CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women

Published Date:

Jan 20 2012

Publisher's site:

http://dx.doi.org/10.1371/journal.pone.0029548 New Site Icon

Source:

PLoS One. 2012; 7(1).

[PDF-151.27 KB]

Details:

Personal Authors:

Azrak, Sami ; Ayyasamy, Vanniarajan ; Zirpoli, Gary ; Ambrosone, Christine ; Bandera, Elisa V. ; ... More ▼

Keywords:

[+]

Pubmed ID:

22276120

Pubmed Central ID:

PMC3262786

Description:

The DNA polymerase-gamma (POLG) gene, which encodes the catalytic subunit of enzyme responsible for directing mitochondrial DNA replication in humans, contains a polyglutamine tract encoded by CAG repeats of varying length. The length of the CAG repeat has been associated with the risk of testicular cancer, and other genomic variants that impact mitochondrial function have been linked to breast cancer risk in African-American (AA) women. We evaluated the potential role of germline POLG-CAG repeat variants in breast cancer risk in a sample of AA women (100 cases and 100 age-matched controls) who participated in the Women's Circle of Health Study, an ongoing multi-institutional, case-control study of breast cancer. Genotyping was done by fragment analysis in a blinded manner. Results from this small study suggest the possibility of an increased risk of breast cancer in women with minor CAG repeat variants of POLG, but no statistically significant differences in CAG repeat length were observed between cases and controls (multivariate-adjusted odds ratio 1.74; 95% CI, 0.49-6.21). Our study suggests that POLG-CAG repeat length is a potential risk factor for breast cancer that needs to be explored in larger population-based studies.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP07-703/DP/NCCDPHP CDC HHS/United States
K22 CA138563/CA/NCI NIH HHS/United States
N01-PC-95001-20/PC/NCI NIH HHS/United States
R01 116430/PHS HHS/United States
R01 121904/PHS HHS/United States
R01 CA100598/CA/NCI NIH HHS/United States
R21 153097/PHS HHS/United States

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