Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0029548
Personal Author:
Azrak, Sami ; Ayyasamy, Vanniarajan ; Zirpoli, Gary ; Ambrosone, Christine ; Bandera, Elisa V. ; ... More +
Azrak, Sami ; Ayyasamy, Vanniarajan ; Zirpoli, Gary ; Ambrosone, Christine ; Bandera, Elisa V. ; Bovbjerg, Dana H. ; Jandorf, Lina ; Ciupak, Gregory ; Davis, Warren ; Pawlish, Karen S. ; Liang, Ping ; Singh, Keshav ; Less -
Description:
The DNA polymerase-gamma (POLG) gene, which encodes the catalytic subunit of enzyme responsible for directing mitochondrial DNA replication in humans, contains a polyglutamine tract encoded by CAG repeats of varying length. The length of the CAG repeat has been associated with the risk of testicular cancer, and other genomic variants that impact mitochondrial function have been linked to breast cancer risk in African-American (AA) women. We evaluated the potential role of germline POLG-CAG repeat variants in breast cancer risk in a sample of AA women (100 cases and 100 age-matched controls) who participated in the Women's Circle of Health Study, an ongoing multi-institutional, case-control study of breast cancer. Genotyping was done by fragment analysis in a blinded manner. Results from this small study suggest the possibility of an increased risk of breast cancer in women with minor CAG repeat variants of POLG, but no statistically significant differences in CAG repeat length were observed between cases and controls (multivariate-adjusted odds ratio 1.74; 95% CI, 0.49-6.21). Our study suggests that POLG-CAG repeat length is a potential risk factor for breast cancer that needs to be explored in larger population-based studies.
Subject:
[+]
Adult
African Americans
Aged
Biology
Breast Neoplasms
Case-Control Studies
DNA, Mitochondrial
DNA-Directed DNA Polymerase
Female
Genetic Predisposition To Disease
Germ-Line Mutation
Humans
Medicine
Middle Aged
Research Article
Risk Factors
Trinucleotide Repeats

Source:
PLoS One. 2012; 7(1).
Pubmed ID:
22276120
Pubmed Central ID:
PMC3262786
Document Type:
Journal Article ;
Funding:
DP07-703/DP/NCCDPHP CDC HHS/United States ; K22 CA138563/CA/NCI NIH HHS/United States ; N01-PC-95001-20/PC/NCI NIH HHS/United States ; R01 116430/PHS HHS/United States ; R01 121904/PHS HHS/United States ; ... More +
DP07-703/DP/NCCDPHP CDC HHS/United States ; K22 CA138563/CA/NCI NIH HHS/United States ; N01-PC-95001-20/PC/NCI NIH HHS/United States ; R01 116430/PHS HHS/United States ; R01 121904/PHS HHS/United States ; R01 CA100598/CA/NCI NIH HHS/United States ; R21 153097/PHS HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:e2c4f01be7ebd0dd08fa9e99389711f7e5ae069ab1cc1b1458aaed515565a0a5
File Type:

Supporting Files

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