Mirna Expression Profiles Identify Drivers in Colorectal and Pancreatic Cancers

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Piepoli, Ada ; Tavano, Francesca ; Copetti, Massimiliano ; Mazza, Tommaso ; Palumbo, Orazio ; Panza, Anna ; di Mola, Francesco Fabio ; Pazienza, Valerio ; Mazzoccoli, Gianluigi ; Biscaglia, Giuseppe ; Gentile, Annamaria ; Mastrodonato, Nicola ; Carella, Massimo ; Pellegrini, Fabio ; di Sebastiano, Pierluigi ; Andriulli, Angelo
• Description:
  Background and Aim
  
  Altered expression of microRNAs (miRNAs) hallmarks many cancer types. The study of the associations of miRNA expression profile and cancer phenotype could help identify the links between deregulation of miRNA expression and oncogenic pathways.
  
  Methods
  
  Expression profiling of 866 human miRNAs in 19 colorectal and 17 pancreatic cancers and in matched adjacent normal tissues was investigated. Classical paired t-test and random forest analyses were applied to identify miRNAs associated with tissue-specific tumors. Network analysis based on a computational approach to mine associations between cancer types and miRNAs was performed.
  
  Results
  
  The merge between the two statistical methods used to intersect the miRNAs differentially expressed in colon and pancreatic cancers allowed the identification of cancer-specific miRNA alterations. By miRNA-network analysis, tissue-specific patterns of miRNA deregulation were traced: the driving miRNAs were miR-195, miR-1280, miR-140-3p and miR-1246 in colorectal tumors, and miR-103, miR-23a and miR-15b in pancreatic cancers.
  
  Conclusion
  
  MiRNA expression profiles may identify cancer-specific signatures and potentially useful biomarkers for the diagnosis of tissue specific cancers. miRNA-network analysis help identify altered miRNA regulatory networks that could play a role in tumor pathogenesis.
  
  
• Subjects:
  Cluster Analysis Colorectal Neoplasms Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Humans MicroRNAs Pancreatic Neoplasms Reproducibility Of Results
• Source:
  PLoS One. 2012; 7(3).
• Pubmed ID:
  22479426
• Pubmed Central ID:
  PMC3316496
• Document Type:
  Journal Article
• Funding:
  RC0903CH47/CH/OID CDC HHS/United States ; RC0903GA51/RC/CCR NIH HHS/United States ; RC1003BS14/BS/FDA HHS/United States ; RC1003CH50/CH/OID CDC HHS/United States ; RC1003GA52/RC/CCR NIH HHS/United States ; RC1103CH46/CH/OID CDC HHS/United States ; RC1103GA47/RC/CCR NIH HHS/United States
• Volume:
  7
• Issue:
  3
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0965468352f0d17e8c1f1ac183aa35c915d904c1afccda54bffd7c112f707cfc
• Download URL:
  https://stacks.cdc.gov/view/cdc/22746/cdc_22746_DS1.pdf
• File Type:
  [PDF - 694.76 KB ]