Details:

Alternative Title:
Environ Health Perspect
Publisher's site:
http://dx.doi.org/10.1289/ehp.1104017
Personal Author:
McAuliffe, Megan E. ; Williams, Paige L. ; Korrick, Susan A. ; Altshul, Larisa M. ; Perry, Melissa J.
McAuliffe, Megan E. ; Williams, Paige L. ; Korrick, Susan A. ; Altshul, Larisa M. ; Perry, Melissa J. Less -
Description:
Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention.|We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy.|We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters.|The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy.|Our findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings.
Subject:
[+]
Adult
Aneuploidy
Chromosomes, Human, Y
Cross-Sectional Studies
Dichlorodiphenyl Dichloroethylene
Environmental Exposure
Humans
In Situ Hybridization, Fluorescence
Male
Poisson Distribution
Polychlorinated Biphenyls
Regression Analysis
Sex Chromosome Aberrations
Spermatozoa

Source:
Environ Health Perspect. 2012; 120(4):535-540.
Pubmed ID:
22189045
Pubmed Central ID:
PMC3339457
Document Type:
Journal Article
Funding:
ES 000002/ES/NIEHS NIH HHS/United States ; ES 009718/ES/NIEHS NIH HHS/United States ; R01 ES017457/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States
ES 000002/ES/NIEHS NIH HHS/United States ; ES 009718/ES/NIEHS NIH HHS/United States ; R01 ES017457/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States Less -
Place as Subject:
Massachusetts
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:6b4dfd82fd05cb0d1e7c9ecff2d77eb329ad70dd3a67098704a4b7e43a03d0fe
File Type:

Supporting Files

• 	ehp.1104017.nxml	txt
  	license.txt	txt

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