Environmental Exposure to Polychlorinated Biphenyls and p,p´-DDE and Sperm Sex-Chromosome Disomy
Published Date:Dec 21 2011
Source:Environ Health Perspect. 2012; 120(4):535-540.
Chromosomes, Human, Y
In Situ Hybridization
In Situ Hybridization, Fluorescence
Polychlorinated Biphenyls (PCBs)
Sex Chromosome Aberrations
Pubmed Central ID:PMC3339457
Funding:ES 000002/ES/NIEHS NIH HHS/United States
ES 009718/ES/NIEHS NIH HHS/United States
R01 ES017457/ES/NIEHS NIH HHS/United States
T42 OH008416/OH/NIOSH CDC HHS/United States
Description:Chromosomal abnormalities contribute substantially to reproductive problems, but the role of environmental risk factors has received little attention.|We evaluated the association of polychlorinated biphenyl (PCB) and dichlorodiphenyldichloroethylene (p,p'-DDE) exposures with sperm sex-chromosome disomy.|We conducted a cross-sectional study of 192 men from subfertile couples. We used multiprobe fluorescence in situ hybridization (FISH) for chromosomes X, Y, and 18 to determine XX, YY, XY, and total sex-chromosome disomy in sperm nuclei. Serum was analyzed for concentrations of 57 PCB congeners and p,p'-DDE. Poisson regression models were used to calculate incidence rate ratios (IRRs) for disomy by exposure quartiles, controlling for demographic characteristics and semen parameters.|The median percent disomy was 0.3 for XX and YY, 0.9 for XY, and 1.6 for total sex-chromosome disomy. We observed a significant trend of increasing IRRs for increasing quartiles of p,p'-DDE in XX, XY, and total sex-chromosome disomy, and a significant trend of increasing IRRs for increasing quartiles of PCBs for XY and total sex-chromosome disomy; however, there was a significant inverse association for XX disomy.|Our findings suggest that exposure to p,p'-DDE may be associated with increased rates of XX, XY, and total sex-chromosome disomy, whereas exposure to PCBs may be associated with increased rates of YY, XY, and total sex-chromosome disomy. In addition, we observed an inverse association between increased exposure to PCBs and XX disomy. Further work is needed to confirm these findings.
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