Details:

Alternative Title:
Emerg Infect Dis
Publisher's site:
http://dx.doi.org/10.3201/eid1806.111590
Personal Author:
Kirkcaldy, Robert D. ; Augostini, Peter ; Asbel, Lenore E. ; Bernstein, Kyle T. ; Kerani, Roxanne P. ; ... More +
Kirkcaldy, Robert D. ; Augostini, Peter ; Asbel, Lenore E. ; Bernstein, Kyle T. ; Kerani, Roxanne P. ; Mettenbrink, Christie J. ; Pathela, Preeti ; Schwebke, Jane R. ; Secor, W. Evan ; Workowski, Kimberly A. ; Davis, Darlene ; Braxton, Jim ; Weinstock, Hillard S. Less -
Description:
Nitroimidazoles (metronidazole and tinidazole) are the only recommended drugs for treating Trichomonas vaginalis infection, and previous samples that assessed resistance of such isolates have been limited in geographic scope. We assessed the prevalence of in vitro aerobic metronidazole and tinidazole resistance among T. vaginalis isolates from multiple geographic sites in the United States. Swab specimens were obtained from women who underwent routine pelvic examinations at sexually transmitted disease clinics in 6 US cities. Cultured T. vaginalis isolates were tested for nitroimidazole resistance (aerobic minimum lethal concentration [MLC] >50 µg/mL). Of 538 T. vaginalis isolates, 23 (4.3%) exhibited low-level in vitro metronidazole resistance (minimum lethal concentrations 50-100 µg/mL). No isolates exhibited moderate- to high-level metronidazole resistance or tinidazole resistance. Results highlight the possibility that reliance on a single class of antimicrobial drugs for treating T. vaginalis infections may heighten vulnerability to emergence of resistance. Thus, novel treatment options are needed.
Subject:
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Adolescent
Adult
Aged
Anti-Bacterial Agents
Drug Resistance, Bacterial
Female
Humans
Metronidazole
Microbial Sensitivity Tests
Middle Aged
Sentinel Surveillance
Sexually Transmitted Diseases
Sexually Transmitted Diseases, Bacterial
Trichomonas Vaginitis
Young Adult

Source:
Emerg Infect Dis. 18(6):939-943.
Document Type:
Journal Article
Funding:
PS08-865/PS/NCHHSTP CDC HHS/United States
Place as Subject:
United States
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:ba2f4747e07188b79799305bb1af6713090fbf2dc578f39f78d83bb1ca3214de
File Type:

Supporting Files

• 	11-1590-F.gif	gif
  	11-1590-F.jpg	jpeg
  	11-1590_finalR.nxml	txt
  	license.txt	txt

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