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Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up
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Details:
  • Corporate Authors:
    on behalf of the TEDDY Study Group ; SEARCH Study Group ; Swediabkids Study Group ; ... More ▼
  • Pubmed ID:
    21972409
  • Pubmed Central ID:
    PMC3198296
  • Description:
    OBJECTIVE

    Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries.

    RESEARCH DESIGN AND METHODS

    Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register).

    RESULTS

    A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register.

    CONCLUSIONS

    Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.

  • Document Type:
  • Collection(s):
  • Funding:
    1U18DP002709/DP/NCCDPHP CDC HHS/United States
    DK-63790/DK/NIDDK NIH HHS/United States
    DK-63821/DK/NIDDK NIH HHS/United States
    DK-63829/DK/NIDDK NIH HHS/United States
    DK-63836/DK/NIDDK NIH HHS/United States
    DK-63861/DK/NIDDK NIH HHS/United States
    DK-63863/DK/NIDDK NIH HHS/United States
    DK-63865/DK/NIDDK NIH HHS/United States
    U01 DK063865/DK/NIDDK NIH HHS/United States
    U01 DP000244/DP/NCCDPHP CDC HHS/United States
    U01 DP000246/DP/NCCDPHP CDC HHS/United States
    U01 DP000247/DP/NCCDPHP CDC HHS/United States
    U01 DP000248/DP/NCCDPHP CDC HHS/United States
    U01 DP000250/DP/NCCDPHP CDC HHS/United States
    U01 DP000254/DP/NCCDPHP CDC HHS/United States
    U01DP000245/DP/NCCDPHP CDC HHS/United States
    U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States
    U18DP002708-01/DP/NCCDPHP CDC HHS/United States
    U18DP002710-01/DP/NCCDPHP CDC HHS/United States
    U18DP002714/DP/NCCDPHP CDC HHS/United States
    U58CCU919256/PHS HHS/United States
    UC4 DK063821/DK/NIDDK NIH HHS/United States
    UC4 DK063865/DK/NIDDK NIH HHS/United States
    UL1 RR025014/RR/NCRR NIH HHS/United States
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