Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up

Details

• Alternative Title:
  Diabetes Care
• Personal Author:
  Elding Larsson, Helena ; Vehik, Kendra ; Bell, Ronny ; Dabelea, Dana ; Dolan, Lawrence ; Pihoker, Catherine ; Knip, Mikael ; Veijola, Riitta ; Lindblad, Bengt ; Samuelsson, Ulf ; Holl, Reinhard ; Haller, Michael J.
• Corporate Authors:
  on behalf of the TEDDY Study Group ; SEARCH Study Group ; Swediabkids Study Group ; DPV Study Group ; Finnish Diabetes Registry Study Group
• Description:
  OBJECTIVE
  
  Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries.
  
  RESEARCH DESIGN AND METHODS
  
  Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register).
  
  RESULTS
  
  A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register.
  
  CONCLUSIONS
  
  Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.
  
  
• Subjects:
  Age Factors Age Of Onset Autoantibodies Blood Glucose Child, Preschool Data Collection Diabetes Mellitus, Type 1 Diabetic Ketoacidosis Female Follow-Up Studies Genetic Predisposition To Disease Humans Incidence Infant Infant, Newborn Islets Of Langerhans Longitudinal Studies Male Population Surveillance Prevalence Registries Risk Factors Severity Of Illness Index

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• Source:
  Diabetes Care. 2011; 34(11):2347-2352.
• Pubmed ID:
  21972409
• Pubmed Central ID:
  PMC3198296
• Document Type:
  Journal Article
• Funding:
  1U18DP002709/DP/NCCDPHP CDC HHS/United States ; DK-63790/DK/NIDDK NIH HHS/United States ; DK-63821/DK/NIDDK NIH HHS/United States ; DK-63829/DK/NIDDK NIH HHS/United States ; DK-63836/DK/NIDDK NIH HHS/United States ; DK-63861/DK/NIDDK NIH HHS/United States ; DK-63863/DK/NIDDK NIH HHS/United States ; DK-63865/DK/NIDDK NIH HHS/United States ; U01 DK063865/DK/NIDDK NIH HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U01DP000245/DP/NCCDPHP CDC HHS/United States ; U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States ; U18DP002708-01/DP/NCCDPHP CDC HHS/United States ; U18DP002710-01/DP/NCCDPHP CDC HHS/United States ; U18DP002714/DP/NCCDPHP CDC HHS/United States ; U58CCU919256/PHS HHS/United States ; UC4 DK063821/DK/NIDDK NIH HHS/United States ; UC4 DK063865/DK/NIDDK NIH HHS/United States ; UL1 RR025014/RR/NCRR NIH HHS/United States
• Place as Subject:
  Europe ; United States
• Volume:
  34
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:2aecec827575bcb7113ba25b425737ad3fe7a9f1423d9e482f87a489261b979a
• Download URL:
  https://stacks.cdc.gov/view/cdc/22678/cdc_22678_DS1.pdf
• File Type:
  [PDF - 121.21 KB ]