Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up

Elding Larsson, Helena; Vehik, Kendra; Bell, Ronny; Dabelea, Dana; Dolan, Lawrence; Pihoker, Catherine; Knip, Mikael; Veijola, Riitta; Lindblad, Bengt; Samuelsson, Ulf; Holl, Reinhard; Haller, Michael J.

doi:10.2337/dc11-1026

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Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up

Oct 04 2011

By Elding Larsson, Helena ; Vehik, Kendra ; Bell, Ronny ; ...

http://dx.doi.org/10.2337/dc11-1026

Source: Diabetes Care. 2011; 34(11):2347-2352.

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English

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Details:

Alternative Title:

Diabetes Care

Publisher's site:

http://dx.doi.org/10.2337/dc11-1026

Personal Author:

Elding Larsson, Helena ; Vehik, Kendra ; Bell, Ronny ; Dabelea, Dana ; Dolan, Lawrence ; ... More +

Corporate Authors:

on behalf of the TEDDY Study Group ; SEARCH Study Group ; Swediabkids Study Group ; DPV Study Group ; Finnish Diabetes Registry Study Group

Description:

OBJECTIVE

Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries.

RESEARCH DESIGN AND METHODS

Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register).

RESULTS

A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register.

CONCLUSIONS

Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.

Subject:

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Source:

Diabetes Care. 2011; 34(11):2347-2352.

Pubmed ID:

21972409

Pubmed Central ID:

PMC3198296

Document Type:

Journal Article

Funding:

1U18DP002709/DP/NCCDPHP CDC HHS/United States ; DK-63790/DK/NIDDK NIH HHS/United States ; DK-63821/DK/NIDDK NIH HHS/United States ; DK-63829/DK/NIDDK NIH HHS/United States ; DK-63836/DK/NIDDK NIH HHS/United States ; ... More +