Reduced Prevalence of Diabetic Ketoacidosis at Diagnosis of Type 1 Diabetes in Young Children Participating in Longitudinal Follow-Up
Published Date:Oct 04 2011
Source:Diabetes Care. 2011; 34(11):2347-2352.
Corporate Authors:on behalf of the TEDDY Study Group ; SEARCH Study Group ; Swediabkids Study Group ; ... More ▼
Age Of Onset
Diabetes Mellitus, Type 1
Genetic Predisposition To Disease
Islets Of Langerhans
Severity Of Illness Index
Pubmed Central ID:PMC3198296
Funding:1U18DP002709/DP/NCCDPHP CDC HHS/United States
DK-63790/DK/NIDDK NIH HHS/United States
DK-63821/DK/NIDDK NIH HHS/United States
DK-63829/DK/NIDDK NIH HHS/United States
DK-63836/DK/NIDDK NIH HHS/United States
DK-63861/DK/NIDDK NIH HHS/United States
DK-63863/DK/NIDDK NIH HHS/United States
DK-63865/DK/NIDDK NIH HHS/United States
U01 DK063865/DK/NIDDK NIH HHS/United States
U01 DP000244/DP/NCCDPHP CDC HHS/United States
U01 DP000246/DP/NCCDPHP CDC HHS/United States
U01 DP000247/DP/NCCDPHP CDC HHS/United States
U01 DP000248/DP/NCCDPHP CDC HHS/United States
U01 DP000250/DP/NCCDPHP CDC HHS/United States
U01 DP000254/DP/NCCDPHP CDC HHS/United States
U01DP000245/DP/NCCDPHP CDC HHS/United States
U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States
U18DP002708-01/DP/NCCDPHP CDC HHS/United States
U18DP002710-01/DP/NCCDPHP CDC HHS/United States
U18DP002714/DP/NCCDPHP CDC HHS/United States
U58CCU919256/PHS HHS/United States
UC4 DK063821/DK/NIDDK NIH HHS/United States
UC4 DK063865/DK/NIDDK NIH HHS/United States
UL1 RR025014/RR/NCRR NIH HHS/United States
Young children have an unacceptably high prevalence of diabetic ketoacidosis (DKA) at the clinical diagnosis of type 1 diabetes. The aim of this study was to determine whether knowledge of genetic risk and close follow-up for development of islet autoantibodies through participation in The Environmental Determinants of Diabetes in the Young (TEDDY) study results in lower prevalence of DKA at diabetes onset in children aged <2 and <5 years compared with population-based incidence studies and registries.
RESEARCH DESIGN AND METHODS
Symptoms and laboratory data collected on TEDDY participants diagnosed with type 1 diabetes between 2004 and 2010 were compared with data collected during the similar periods from studies and registries in all TEDDY-participating countries (U.S., SEARCH for Diabetes in Youth Study; Sweden, Swediabkids; Finland, Finnish Pediatric Diabetes Register; and Germany, Diabetes Patienten Verlaufsdokumenation [DPV] Register).
A total of 40 children younger than age 2 years and 79 children younger than age 5 years were diagnosed with type 1 diabetes in TEDDY as of December 2010. In children <2 years of age at onset, DKA prevalence in TEDDY participants was significantly lower than in all comparative registries (German DPV Register, P < 0.0001; Swediabkids, P = 0.02; SEARCH, P < 0.0001; Finnish Register, P < 0.0001). The prevalence of DKA in TEDDY children diagnosed at <5 years of age (13.1%) was significantly lower compared with SEARCH (36.4%) (P < 0.0001) and the German DPV Register (32.2%) (P < 0.0001) but not compared with Swediabkids or the Finnish Register.
Participation in the TEDDY study is associated with reduced risk of DKA at diagnosis of type 1 diabetes in young children.
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