Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize
translation

Pavon-Eternod, Mariana; David, Alexandre; Dittmar, Kimberly; Berglund, Peter; Pan, Tao; Bennink, Jack R.; Yewdell, Jonathan W.

doi:10.1093/nar/gks986

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Vaccinia and influenza A viruses select rather than adjust tRNAs to optimize translation

Published Date:

Dec 18 2012

Publisher's site:

http://dx.doi.org/10.1093/nar/gks986 New Site Icon

Source:

Nucleic Acids Res. 2012; 41(3):1914-1921.

[PDF - 3.43 MB]

Details:

Personal Authors:

Pavon-Eternod, Mariana ; David, Alexandre ; Dittmar, Kimberly ; Berglund, Peter ; Pan, Tao ; ... More ▼

Keywords:

[+]

Pubmed ID:

23254333

Pubmed Central ID:

PMC3561966

Description:

Transfer RNAs (tRNAs) are central to protein synthesis and impact translational speed and fidelity by their abundance. Here we examine the extent to which viruses manipulate tRNA populations to favor translation of their own genes. We study two very different viruses: influenza A virus (IAV), a medium-sized (13 kB genome) RNA virus; and vaccinia virus (VV), a large (200 kB genome) DNA virus. We show that the total cellular tRNA population remains unchanged following viral infection, whereas the polysome-associated tRNA population changes dramatically in a virus-specific manner. The changes in polysome-associated tRNA levels reflect the codon usage of viral genes, suggesting the existence of local tRNA pools optimized for viral translation.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DP1 GM105386/DP/NCCDPHP CDC HHS/United States
T32 GM007183/GM/NIGMS NIH HHS/United States

Supporting Files:

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