Toxicity of Anticholinesterase Pesticides in Neonate and Children

Details

• Personal Author:
  McCauley L ; Rohlman D
• Description:
  There is increasing concern regarding the widespread use of pesticides in agricultural communities and potential impacts on public health. Organophosphorous pesticides (OPs) are currently the most commonly utilized pesticides in the world, consisting of nearly 40 different chemical members registered by the United States Environmental Protection Agency (U.S. EPA; www.epa.gov). In the 1990s some 2.5 million to 5.0 million agricultural workers were exposed to OP insecticides in the United States (Das et al., 2001). About 73 million pounds of OP pesticides were used in the United States in 2001 (70% of all insecticides; Kiely, 2004). Scientific field investigations have focused on delineating the extent of exposure and potential health effects in agricultural and nonagricultural communities. Children have been the focus of many of these field investigations. In this chapter we will review the factors that make exposures to anticholinesterase pesticides of major public health concern, including the physiological uniqueness of infants and children, and the behavioral and developmental aspects that increase the likelihood of exposure. Animal models that have shown the particular vulnerability of infants and children will be reviewed, and the major epidemiological studies that are providing scientific information on the population impact will be discussed. Emphasis in this chapter will be on the emerging knowledge of the impact of anticholinesterase pesticides on the neurodevelopment of infants and children. [Description provided by NIOSH]
• Subjects:
  Agriculture Animals Behavior Epidemiology Insecticides Mental Disorders Nervous System Nervous System Diseases Occupational Exposure Occupational Health Organophosphates Pregnancy Public Health Safety

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• Keywords:
  Acute Exposure Agricultural Chemicals Agricultural Industry Agricultural Safety Analytical Models Animal Studies Anticholinesterase Insecticides Behavioral Disorders Children Exposure Assessment Humans Longitudinal Study Neurological Disorders Organophosphorus Insecticides Organophosphorus Pesticides Pesticides Pesticides And Agricultural Chemicals Physiological Factors Prenatal Exposure Public Health

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• ISBN:
  9780470410301
• Publisher:
  John Wiley & Sons, Inc.
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Book
• Place as Subject:
  Georgia ; Iowa ; New Jersey ; Oregon ; OSHA Region 10 ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  225-236
• NIOSHTIC Number:
  nn:20063122
• Citation:
  Anticholinesterase pesticides; metabolism, neurotoxicity, and epidemiology. Satoh T, Gupta RC, eds. Hoboken, NJ: John Wiley & Sons, Inc., 2011 Jan; :225-236
• Contact Point Address:
  Diane Rohlman, Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon
• Editor(s):
  Satoh T; Gupta RC
• Federal Fiscal Year:
  2011
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  False
• Start Date:
  20050701
• Source Full Name:
  Anticholinesterase pesticides; metabolism, neurotoxicity, and epidemiology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b222be3c6763a589b390828ec261e9a8477624f73ab526d4acf9fed8c993d292e3447c5979154f7a98ad1b376a39be4e3d3116801d3753f95cabd089d7501139
• Download URL:
  https://stacks.cdc.gov/view/cdc/226242/cdc_226242_DS1.pdf
• File Type:
  [PDF - 381.53 KB ]