Associations of Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) and PFAS Mixtures with Adipokines in Midlife Women

Details

• Personal Author:
  Calafat, Antonia M. ; Ding N ; Herman WH ; Karvonen-Gutierrez CA ; Mukherjee B ; Park SK
• Description:
  Background: Perfluoroalkyl and polyfluoroalkyl substances (PFAS) exposure have been associated with obesity and related comorbidities, possibly through disrupting signaling pathways of adipokines. Both leptin and adiponectin can modulate metabolic processes. However, the effects of PFAS on adipokines are not well understood. Objective: We determined if serum PFAS concentrations were associated with adipokine profiles in midlife women. Methods: We examined 1245 women aged 45-56 years from the Study of Women's Health Across the Nation. Concentrations of 11 PFAS were quantified in baseline serum samples collected in 1999-2000. Linear and branched perfluorooctane sulfonic acid isomers (n-PFOS and Sm-PFOS) and their sum (PFOS), linear perfluorooctanoic acid (n-PFOA), perfluorononanoic acid (PFNA), perfluorohexane sulfonic acid (PFHxS), 2-(N-methyl-perfluorooctane sulfonamido) acetic acid (MeFOSAA), and 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid (EtFOSAA) with detection frequencies >60% were included in the analysis. Adipokines including leptin, soluble leptin receptor (sOB-R), free leptin index (FLI, the ratio of leptin to sOB-R), total and high molecular weight (HMW) adiponectin were assessed in 2002-2003. We utilized multivariable linear regressions and Bayesian kernel machine regression (BKMR) to assess individual and overall joint effects of PFAS on adipokines with adjustment for age, race/ethnicity, study site, education, smoking status, physical activity, menopausal status, and waist circumference. Results: A doubling of PFAS concentrations was associated with 7.8% (95% CI: 2.5%, 13.4%) higher FLI for PFOS, 9.4% (95% CI: 3.7%, 15.3%) for n-PFOA, 5.5% (95% CI: 2.2%, 9.0%) for EtFOSAA and 7.4% (95% CI: 2.8%, 12.2%) for MeFOSAA. Similar associations were found for leptin. Only EtFOSAA was associated with lower sOB-R concentrations (-1.4%, 95% CI: -2.7%, -0.1%). Results remained in women with overweight or obesity but not those with normal weight or underweight. No statistically significant associations were observed with total or HMW adiponectin, except for PFNA with total and HMW adiponectin observed in women with normal weight or underweight. In BKMR analysis, women with PFAS concentrations at the median and the 90th percentile had 30.9% (95% CI: 15.6%, 48.3%) and 52.1% (95% CI: 27.9%, 81.0%) higher FLI, respectively, compared with those with concentrations fixed at the 10th percentile. Conclusion: Some PFAS may alter circulating levels of leptin. Understanding associations between PFAS and adipokines may help elucidate whether PFAS can influence obesity and metabolic disease. [Description provided by NIOSH]
• Subjects:
  Blood Body Weight Endocrine System Occupational Health Safety Women
• Keywords:
  (PFAS) Adipokines Adiponectin Adipose Tissue Author Keywords: Perfluoroalkyl And Polyfluoroalkyl Substances Blood Serum Body Weight Cellular Reactions Hormone Activity Hormones Leptin Metabolic Disorders Obesity Per- And Polyfluoroalkyl Substances PFAS

  More +
• ISSN:
  1438-4639
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Michigan ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  235
• NIOSHTIC Number:
  nn:20063026
• Citation:
  Int J Hyg Environ Health 2021 Jun; 235:113777
• Contact Point Address:
  Sung Kyun Park, Department of Epidemiology, University of Michigan, M5541 SPH II, 1415 Washington Heights, Ann Arbor, MI 48109-2029, USA
• Email:
  sungkyun@umich.edu
• CAS Registry Number:
  Perfluorocarbons (CAS RN 308069-13-8)
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Hygiene and Environmental Health
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:793cfe8dc2c723f698c6eea000a08cd486217633f508660fe08e4ffd2c2a504eb090150267cdb5b6a402bc8504814eeea2f0a3782a7c360316375be0c690bd6a
• Download URL:
  https://stacks.cdc.gov/view/cdc/226157/cdc_226157_DS1.pdf
• File Type:
  [PDF - 2.54 MB ]