Utilizing Literature-Based Rodent Toxicology Data to Derive Potency Estimates for Quantitative Risk Assessment

Details

• Personal Author:
  Boots TE ; Drew NM ; Kogel AM ; Kuempel, Eileen D.
• Description:
  Evaluating the potential occupational health risk of engineered nanomaterials is an ongoing need. The objective of this meta-analysis, which consisted of 36 studies containing 86 materials, was to assess the availability of published in vivo rodent pulmonary toxicity data for a variety of nanoscale and microscale materials and to derive potency estimates via benchmark dose modeling. Additionally, the potency estimates based on particle mass lung dose associated with acute pulmonary inflammation were used to group materials based on toxicity. The commonalities among the physicochemical properties of the materials in each group were also explored. This exploration found that a material's potency tended to be associated primarily with the material class based on chemical composition and form (e.g. carbon nanotubes, TiO2, ZnO) rather than with particular physicochemical properties. Limitations in the data available precluded a more extensive analysis of these associations. Issues such as data reporting and appropriate experimental design for use in quantitative risk assessment are the main reasons publications were excluded from these analyses and are discussed. [Description provided by NIOSH]
• Subjects:
  Engineering Lung Occupational Health Particulate Matter Respiratory System Safety Toxicology
• Keywords:
  Author Keywords: Meta-analysis Benchmark Dose Modeling Carbon Nanotubes CNT Dose Response In Vivo Study Nanomaterials Particulates Potency Estimation Quantitative Risk Assessment Risk Assessment Rodents

  More +
• ISSN:
  1743-5390
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Tennessee ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DSI - Division of Science Integration
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  15
• Issue:
  6
• NIOSHTIC Number:
  nn:20062935
• Citation:
  Nanotoxicology 2021 Jul; 15(6):740-760
• Contact Point Address:
  Theresa Eileen Boots, BioAnalytics Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Rd, Morgantown, WV 26505-2888, USA
• Email:
  oph6@cdc.gov
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Public Safety ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Nanotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d9072dd3a6991ea340c592b5eba39fda7f2a5d54c2ec9cec02731f1af50bace24cdc77dbe8c357f5bc34bca6ea6530ad0167b6c031a9ffc9562db78b153528a2
• Download URL:
  https://stacks.cdc.gov/view/cdc/226098/cdc_226098_DS1.pdf
• File Type:
  [PDF - 2.96 MB ]