Electrochemical Paper-Based Devices: Sensing Approaches and Progress Toward Practical Applications

Details

• Personal Author:
  Clark KM ; Henry CS ; Jang I ; McCord CP ; Noviana E
• Description:
  Paper-based sensors offer an affordable yet powerful platform for field and point-of-care (POC) testing due to their self-pumping ability and utility for many different analytical measurements. When combined with electrochemical detection using small and portable electronics, sensitivity and selectivity of the paper devices can be improved over naked eye detection without sacrificing portability. Herein, we review how the field of electrochemical paper-based analytical devices (ePADs) has grown since it was introduced a decade ago. We start by reviewing fabrication methods relevant to ePADs with more focus given to the electrode fabrication, which is fundamental for electrochemical sensing. Multiple sensing approaches applicable to ePADs are then discussed and evaluated to present applicability, advantages and challenges associated with each approach. Recent applications of ePADs in the fields of clinical diagnostics, environmental testing, and food analysis are also presented. Finally, we discuss how the current ePAD technologies have progressed to meet the analytical and practical specifications required for field and/or POC applications, as well as challenges and outlook. Correction: In the original article, there was an error in the references given in the Fig. 2 caption. The corrected caption can be viewed here: https://doi.org/10.1039/C9LC90124H. [Description provided by NIOSH]
• Subjects:
  Electrical Equipment And Supplies Laboratories Occupational Health Safety
• Keywords:
  Analytical Instruments Analytical Methods Detectors Electrochemical Analysis Electronic Devices Equipment Design Equipment Testing Laboratory Testing Sensors
• ISSN:
  1473-0197
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9-34
• Volume:
  20
• Issue:
  1
• NIOSHTIC Number:
  nn:20062896
• Citation:
  Lab Chip 2020 Jan; 20(1):9-34
• Contact Point Address:
  Charles S. Henry, Department of Chemistry, Colorado State University, Fort Collins, CO, USA
• Email:
  Chuck.Henry@colostate.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  Colorado State University, Fort Collins
• Peer Reviewed:
  True
• Start Date:
  20150901
• Source Full Name:
  Lab on a Chip
• End Date:
  20190831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:154da807bc05503e654f2567d52e15449e282c9b1415780c8f2760f5c0e144df83ea652d7211bc7b7872ef583d6078279961cfe177485e8ba95e1578f12181a0
• Download URL:
  https://stacks.cdc.gov/view/cdc/226066/cdc_226066_DS1.pdf
• File Type:
  [PDF - 13.00 MB ]