Associations Between Patella Lead and Blood Pressure in Lead Workers

Details

• Personal Author:
  Ahn K-D ; Ellis LR ; Lee B-K ; Schwartz BS ; Shi W ; Todd AC ; Weaver VM
• Description:
  Background: To compare associations of patella lead, a lead pool that may capture aspects of both current bioavailable and cumulative lead dose thus offering advantages over tibia or blood lead, with blood lead in models of blood pressure and hypertension and to examine effect modification by age, sex and polymorphisms of the genes encoding for the vitamin D receptor (VDR) and d-aminolevulinic acid dehydratase (ALAD). Methods: Cross-sectional data in 652 current and former lead workers were analyzed. Results: Blood lead, but not patella lead, was positively associated with systolic blood pressure. Neither lead measure was associated with diastolic blood pressure or hypertension status. There was no evidence of effect modification. Conclusions: In these workers, blood lead was more relevant to elevations in blood pressure than was patella lead. Additional research will be required to determine whether patella lead assessment provides unique information on vascular risk from lead exposure. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Genetics Lead Occupational Exposure Occupational Health Safety
• Keywords:
  Author Keywords: Blood Lead Biological Monitoring Blood Lead Levels Blood Pressure Cardiovascular Disease Cross Sectional Studies D-aminolevulinic Acid Dehydratase Genes Hypertension Occupational Exposure Occupational Lead Exposure Patella Lead Vitamin D Receptor

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; New York ; OSHA Region 2 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  336-343
• Volume:
  51
• Issue:
  5
• NIOSHTIC Number:
  nn:20062850
• Citation:
  Am J Ind Med 2008 May; 51(5):336-343
• Contact Point Address:
  Dr. Virginia M. Weaver, Division of Occupational and Environmental Health, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Room 7041, Baltimore, MD 21205
• Email:
  vweaver@jhsph.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Johns Hopkins University
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c0bb2ca4e0674eed9bf8a304e7b8407f5cd7aafebf1d9e9c3fd66c3c5b0f560b0bcda2cd960f14c1534e03a3bfe9b844745b0686b4ff30cec8d2c959f71bdf1
• Download URL:
  https://stacks.cdc.gov/view/cdc/226025/cdc_226025_DS1.pdf
• File Type:
  [PDF - 100.35 KB ]