Acute Changes in Thyroid Hormone Levels Among Thai Pesticide Sprayers

Details

• Personal Author:
  Choochouy N ; Chungcharoen J ; Kallayanatham N ; Khangkhun P ; Kongtip P ; Konthonbut P ; Nankongnab N ; Pengpumkiat S ; Phommalachai C ; Pundee R ; Sowanthip P ; Woskie S ; Yimsabai J
• Description:
  The objective of this study was to investigate the relationship of acute pesticide exposures and acute changes in thyroid hormones among Thai farmers. We recruited 78 farmers, who were scheduled to spray insecticides (chlorpyrifos and/or cypermethrin) or herbicides (paraquat and/or glyphosate). On the day before spraying, farmers collected their first morning void urine and went for blood collection. On the spray day, urine samples were collected at end of the spraying event and they were interviewed with questionnaires. The next morning, the first morning void urine and blood samples were collected. Blood samples were analyzed for thyroid hormones. Urine samples were analyzed for the metabolites of the pesticide sprayed. The results showed that the thyroid hormones, free triiodothyronine (FT3) and total triiodothyronine (T3) were significantly reduced as urinary chlorpyrifos metabolite increased the day after spraying. Total thyroxine (T4) significantly increased as cypermethrin metabolites increased the day after spraying. T4 significantly increased as urinary glyphosate levels increased; however, FT3 and T3 decreased significantly as urinary paraquat levels increased the day after spraying. These findings suggest that acute exposures to the pesticides chlorpyrifos, cypermethrin, paraquat and glyphosate can produce acute effects on the hypothalamic-pituitary-thyroid (HPT) axis, acutely altering thyroid hormone levels. [Description provided by NIOSH]
• Subjects:
  Agriculture Endocrine System Farmers Fungi Fungicide, Industrial Hazardous Substances Herbicides Insecticides Occupational Exposure Occupational Health Safety

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• Keywords:
  Acute Exposure Agricultural Chemicals Agricultural Workers Author Keywords: Acute Exposure Chemical Hazards Chemicals Chlorpyrifos Cypermethrin Employee Exposure Endocrine Disrupter Endocrine System Endocrine System Disorders Farm Workers Fungicides Glyphosate Hormone Activity Hormones Humans Paraquat Pesticides Pesticides And Agricultural Chemicals Spraying Operations Thyroid Gland Thyroid Hormones

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• ISSN:
  2305-6304
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Massachusetts ; OSHA Region 1 ; OSHA Region 3
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  16
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20062641
• Citation:
  Toxics 2021 Jan; 9(1):16
• Contact Point Address:
  Pornpimol Kongtip, Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, 420/1 Rajvidhi Road, Bangkok 10400, Thailand
• Email:
  pornpimol.kon@mahidol.ac.th
• CAS Registry Number:
  Chlorpyrifos (CAS RN 2921-88-2) ; Cypermethrin (CAS RN 52315-07-8) ; Glyphosate (CAS RN 1071-83-6) ; Methyl viologen (CAS RN 1910-42-5)
• Federal Fiscal Year:
  2021
• Performing Organization:
  Mahidol University, Nakhon Pathom, Thailand
• Peer Reviewed:
  True
• Start Date:
  20150928
• Source Full Name:
  Toxics
• End Date:
  20210731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1950f5dea77e11fcdd6d1b75034e6ac6eeb0c7f1a134f895a6132ac7bf2daf2527986df5b2c1e87155be514a6ce2763d48cab2a2d44c0fa2d5cc03ddc7c844cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/225846/cdc_225846_DS1.pdf
• File Type:
  [PDF - 371.64 KB ]