Risk of Spina Bifida and Maternal Cigarette, Alcohol, and Coffee Use during the First Month of Pregnancy

Benedum, Corey M.; Yazdy, Mahsa M.; Mitchell, Allen A.; Werler, Martha M.

doi:10.3390/ijerph10083263

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Risk of Spina Bifida and Maternal Cigarette, Alcohol, and Coffee Use during the First Month of Pregnancy

Published Date:

Aug 02 2013

Publisher's site:

http://dx.doi.org/10.3390/ijerph10083263 New Site Icon

Source:

Int J Environ Res Public Health. 2013; 10(8):3263-3281.

[PDF-707.93 KB]

Details:

Personal Authors:

Benedum, Corey M. ; Yazdy, Mahsa M. ; Mitchell, Allen A. ; Werler, Martha M. ;

Keywords:

[+]

Pubmed ID:

23917813

Pubmed Central ID:

PMC3774437

Description:

This study was conducted to assess the association between the risks of spina bifida (SB) in relation to cigarette, alcohol, and caffeine consumption by women during the first month of pregnancy. Between 1988-2012, this multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures. We evaluated cigarette smoking, frequency of alcohol drinking, and caffeine intake during the first lunar month of pregnancy in relation to SB risk. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Levels of cigarette smoking (1-9 and ≥10/day), alcohol intake (average ≥4 drinks/day) and caffeine intake (<1, 1, and ≥2 cups/day) were not likely to be associated with increased risk of SB. Further, results were similar among women who ingested less than the recommended amount of folic acid (400 μg/day).

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

DD000697/DD/NCBDD CDC HHS/United States

Supporting Files:

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	ijerph-10-03263-g001.jpg	image/jpeg
	ijerph-10-03263-i001.jpg	image/jpeg
	ijerph-10-03263.nxml	text/plain
	license.txt	text/plain

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