Risk of Spina Bifida and Maternal Cigarette, Alcohol, and Coffee Use during the First Month of Pregnancy

Details

• Alternative Title:
  Int J Environ Res Public Health
• Personal Author:
  Benedum, Corey M. ; Yazdy, Mahsa M. ; Mitchell, Allen A. ; Werler, Martha M.
• Description:
  This study was conducted to assess the association between the risks of spina bifida (SB) in relation to cigarette, alcohol, and caffeine consumption by women during the first month of pregnancy. Between 1988-2012, this multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures. We evaluated cigarette smoking, frequency of alcohol drinking, and caffeine intake during the first lunar month of pregnancy in relation to SB risk. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Levels of cigarette smoking (1-9 and ≥10/day), alcohol intake (average ≥4 drinks/day) and caffeine intake (<1, 1, and ≥2 cups/day) were not likely to be associated with increased risk of SB. Further, results were similar among women who ingested less than the recommended amount of folic acid (400 μg/day).
• Subjects:
  Adolescent Adult Alcohol Consumption Alcohol Drinking Article Birth Defects Caffeine Caffeine Consumption Case-Control Studies Cigarettes Coffee Female Folic Acid Humans Logistic Models Pregnancy Pregnancy Trimester, First Risk Factors Smoking Spina Bifida Spinal Dysraphism Young Adult

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• Source:
  Int J Environ Res Public Health. 2013; 10(8):3263-3281.
• Pubmed ID:
  23917813
• Pubmed Central ID:
  PMC3774437
• Document Type:
  Journal Article
• Funding:
  DD000697/DD/NCBDD CDC HHS/United States
• Volume:
  10
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:432c198a63a742ab734ecbae54fb6ef69dbdd88c50b1a2ca00aa44f5c8e001e2
• Download URL:
  https://stacks.cdc.gov/view/cdc/22569/cdc_22569_DS1.pdf
• File Type:
  [PDF - 707.93 KB ]