Timing of Cervico-Vaginal Cytokine Collection During Pregnancy and Preterm Birth: A Comparative Analysis in the PRINCESA Cohort

Details

• Personal Author:
  Buxton MA ; Castillo-Castrejon M ; Foxman B ; Meraz-Cruz N ; O'Neill MS ; Sanchez BN ; Vadillo-Ortega F
• Description:
  Preterm birth (PTB), defined as birth before 37 completed weeks of gestation, is a major cause of infant morbidity and mortality. Inflammation is an important component in the physiopathologic pathway leading to PTB but results from cross-sectional studies on associations between inflammation, as measured by cytokines, and PTB are inconsistent. Timing of cytokine measurement during pregnancy varies between studies and may contribute to inconsistent findings. We investigated the effects of timing on associations between 16 cervico-vaginal cytokines (Eotaxin, IL-10, IL-12p40, IL-17, IL-1RA, sIL-2ralpha, IL-1a, IL-1beta, IL-2, IL-6, IP-10, MCP-1, MIP-1alpha, MIP-1beta, TNFalpha, and VEGF) and PTB among 90 women throughout pregnancy. We used logistic regression to compare associations between concentrations of cervico-vaginal cytokines from periods in pregnancy and PTB. Trimester 1 cytokines had the strongest positive associations with PTB; for example, OR = 1.76 (95% confidence interval: 1.28, 2.42) for IL-6. Second and third trimester associations were weaker but largely positive. IL-1alpha was the only cytokine with a negative association (trimesters 2, 3 and overall pregnancy). Strong first trimester associations between cytokines and PTB suggest that measuring cytokines early in pregnancy may hold promise for early identification of PTB risk. Variations in cytokine measurement during pregnancy may contribute to inconsistencies among studies. [Description provided by NIOSH]
• Subjects:
  Immune System Occupational Health Pregnancy Risk Assessment Risk Factors Safety Women
• Keywords:
  Author Keywords: Longitudinal Data Collection During Pregnancy Comparative Analysis Cross Sectional Studies Cytokines Immune Reaction Inflammation Physiopathology Preterm Birth Proteins Regression Analysis Risk Factors Sampling Timing Of Sample

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; Oklahoma ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 6 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  7
• NIOSHTIC Number:
  nn:20062395
• Citation:
  Int J Environ Res Public Health 2021 Apr; 18(7):3436
• Contact Point Address:
  Miatta A. Buxton, Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA
• Email:
  mabuxton@umich.edu
• Federal Fiscal Year:
  2021
• Performing Organization:
  University of Michigan, Ann Arbor
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:093bbc48feb543602f14b276e1852493b49c350f3cc9e940373aa4d50a3684a79a859c6c9c439965e750b5d5f2aff2d0ee0931facf1164eb0e813130632a8955
• Download URL:
  https://stacks.cdc.gov/view/cdc/225652/cdc_225652_DS1.pdf
• File Type:
  [PDF - 309.98 KB ]