Early Elevation of Serum MMP-3 and MMP-12 Predicts Protection from World Trade Center-Lung Injury in New York City Firefighters: A Nested Case-Control Study

Kwon, Sophia; Weiden, Michael D.; Echevarria, Ghislaine C.; Comfort, Ashley L.; Naveed, Bushra; Prezant, David J.; Rom, William N.; Nolan, Anna

doi:10.1371/journal.pone.0076099

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Early Elevation of Serum MMP-3 and MMP-12 Predicts Protection from World Trade Center-Lung Injury in New York City Firefighters: A Nested Case-Control Study

Published Date:

Oct 16 2013

Publisher's site:

http://dx.doi.org/10.1371/journal.pone.0076099 New Site Icon

Source:

PLoS One. 2013; 8(10).

[PDF-437.44 KB]

Details:

Personal Authors:

Kwon, Sophia ; Weiden, Michael D. ; Echevarria, Ghislaine C. ; Comfort, Ashley L. ; Naveed, Bushra ; ... More ▼

Keywords:

[+]

Pubmed ID:

24146820

Pubmed Central ID:

PMC3797818

Description:

Objective

After 9/11/2001, some Fire Department of New York (FDNY) workers had excessive lung function decline. We hypothesized that early serum matrix metalloproteinases (MMP) expression predicts World Trade Center-Lung Injury (WTC-LI) years later.

Methods

This is a nested case-control analysis of never-smoking male firefighters with normal pre-exposure Forced Expiratory Volume in one second (FEV1) who had serum drawn up to 155 days post 9/11/2001. Serum MMP-1, 2,3,7,8, 9, 12 and 13 were measured. Cases of WTC-LI (N = 70) were defined as having an FEV1 one standard deviation below the mean (FEV1≤77%) at subspecialty pulmonary evaluation (SPE) which was performed 32 months (IQR 21–53) post-9/11. Controls (N = 123) were randomly selected. We modeled MMP's ability as a predictor of cases status with logistic regression adjusted for time to blood draw, exposure intensity, weight gain and pre-9/11 FEV1.

Results

Each log-increase in MMP-3 and MMP-12 showed reduced odds of developing WTC-LI by 73% and 54% respectively. MMP-3 and MMP-12 consistently clustered together in cases, controls, and the cohort. Increasing time to blood draw significantly and independently increased the risk of WTC-LI.

Conclusions

Elevated serum levels of MMP-3 and MMP-12 reduce the risk of developing WTC-LI. At any level of MMP-3 or 12, increased time to blood draw is associated with a diminished protective effect.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

K24A1080298/PHS HHS/United States
NIEHST32ES007267/ES/NIEHS NIH HHS/United States
NIH-NHLBI K23HL084191/PHS HHS/United States
NIH-R01HL057879/HL/NHLBI NIH HHS/United States
U10-OH008242/OH/NIOSH CDC HHS/United States
U10-OH008243/OH/NIOSH CDC HHS/United States
UL1RR029893/RR/NCRR NIH HHS/United States

Supporting Files:

	pone.0076099.g004.jpg	image/jpeg
	pone.0076099.nxml	text/plain
	pone.0076099.t001.gif	image/gif
	pone.0076099.t001.jpg	image/jpeg
	pone.0076099.t002.gif	image/gif
	pone.0076099.t002.jpg	image/jpeg
	pone.0076099.t003.gif	image/gif
	pone.0076099.t003.jpg	image/jpeg
	pone.0076099.t004.gif	image/gif
	pone.0076099.t004.jpg	image/jpeg
	license.txt	text/plain
	pone.0076099.g001.gif	image/gif
	pone.0076099.g001.jpg	image/jpeg
	pone.0076099.g002.gif	image/gif
	pone.0076099.g002.jpg	image/jpeg
	pone.0076099.g003.gif	image/gif
	pone.0076099.g003.jpg	image/jpeg
	pone.0076099.g004.gif	image/gif

No Related Documents.

You May Also Like:

Biomarkers of World Trade Center Particulate Matter Exposure: Physiology of distal airway and blood biomarkers that predict FEV1 decline

Personal Author:

Weiden, Michael D.; Kwon, Sophia; Caraher, Erin; Berger, Kenneth I.; Reibman, Joan; Rom, William N.; Prezant, David J.; Nolan, Anna;

Published:

May 29 2015

Source:

Semin Respir Crit Care Med. 36(3):323-333.

Description:

Biomarkers can be important predictors of disease severity and progression. The intense exposure to particulates and other toxins from the destruction of the World Trade Center (WTC) overwhelmed the lung's normal protective barriers. The Fire De...

File Type:

[PDF - 469.80 KB]
Biomarkers of Patient Intrinsic Risk for Upper and Lower Airway Injury After Exposure to the World Trade Center Atrocity

Personal Author:

Zeig-Owens, Rachel; Nolan, Anna; Putman, Barbara; Singh, Ankura; Prezant, David J.; Weiden, Michael D.;

Published:

Sep 2016

Source:

Am J Ind Med. 59(9):788-794.

Description:

Background : High rates of upper and lower airways disease have occurred in Fire Department of the City of New York (FDNY) workers exposed to the World Trade Center (WTC) disaster site. Most experienced acute declines in pulmonary function, and some ...

File Type:

[PDF - 383.32 KB]
Non-Cardiac Chest Pain: A Review of Environmental Exposure-Associated Comorbidities and Biomarkers

Personal Author:

Mikhail, Mena; Crowley, George; Haider, Syed Hissam; Veerappan, Arul; Lam, Rachel; Talusan, Angela; Clementi, Emily; Ostrofsky, Dean; Kwon, Sophia; Nolan, Anna;

Published:

Dec 11 2018

Source:

EMJ Gastroenterol. 7(1):103-112

Description:

The prevalence of non-cardiac chest pain (NCCP) ranges from 13-33%. A majority of those presenting with a chief complaint of chest pain are found to have a diagnosis of NCCP. Aerodigestive diseases are a cause of NCCP, and billions of dollars are spe...

File Type:

[PDF - 574.58 KB]
Estimating the Time Interval Between Exposure to the World Trade Center Disaster and Incident Diagnoses of Obstructive Airway Disease

Personal Author:

Glaser, Michelle S.; Webber, Mayris P.; Zeig-Owens, Rachel; Weakley, Jessica; Liu, Xiaoxue; Ye, Fen; Cohen, Hillel W.; Aldrich, Thomas K.; Kelly, Kerry J.; Nolan, Anna; Weiden, Michael D.; Prezant, David J.; Hall, Charles B.;

Published:

Jun 30 2014

Source:

Am J Epidemiol. 2014; 180(3):272-279.

Description:

Respiratory disorders are associated with occupational and environmental exposures. The latency period between exposure and disease onset remains uncertain. The World Trade Center (WTC) disaster presents a unique opportunity to describe the latency p...

File Type:

[PDF - 164.43 KB]
Predictive Biomarkers of Gastroesophageal Reflux Disease and Barrett’s Esophagus in World Trade Center Exposed Firefighters: a 15 Year Longitudinal Study

Personal Author:

Haider, Syed H.; Kwon, Sophia; Lam, Rachel; Lee, Audrey K.; Caraher, Erin J.; Crowley, George; Zhang, Liqun; Schwartz, Theresa M.; Zeig-Owens, Rachel; Liu, Mengling; Prezant, David J.; Nolan, Anna;

Published:

Feb 15 2018

Source:

Sci Rep. 8.

Description:

Gastroesophageal reflux disease (GERD) and Barrett's Esophagus (BE), which are prevalent in the World Trade Center (WTC) exposed and general populations, negatively impact quality of life and cost of healthcare. GERD, a risk factor of BE, is linked ...

File Type:

[PDF - 1.29 MB]