Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0076099
Personal Author:
Kwon, Sophia ; Weiden, Michael D. ; Echevarria, Ghislaine C. ; Comfort, Ashley L. ; Naveed, Bushra ; ... More +
Kwon, Sophia ; Weiden, Michael D. ; Echevarria, Ghislaine C. ; Comfort, Ashley L. ; Naveed, Bushra ; Prezant, David J. ; Rom, William N. ; Nolan, Anna ; Less -
Description:
Objective After 9/11/2001, some Fire Department of New York (FDNY) workers had excessive lung function decline. We hypothesized that early serum matrix metalloproteinases (MMP) expression predicts World Trade Center-Lung Injury (WTC-LI) years later. Methods This is a nested case-control analysis of never-smoking male firefighters with normal pre-exposure Forced Expiratory Volume in one second (FEV1) who had serum drawn up to 155 days post 9/11/2001. Serum MMP-1, 2,3,7,8, 9, 12 and 13 were measured. Cases of WTC-LI (N = 70) were defined as having an FEV1 one standard deviation below the mean (FEV1≤77%) at subspecialty pulmonary evaluation (SPE) which was performed 32 months (IQR 21–53) post-9/11. Controls (N = 123) were randomly selected. We modeled MMP's ability as a predictor of cases status with logistic regression adjusted for time to blood draw, exposure intensity, weight gain and pre-9/11 FEV1. Results Each log-increase in MMP-3 and MMP-12 showed reduced odds of developing WTC-LI by 73% and 54% respectively. MMP-3 and MMP-12 consistently clustered together in cases, controls, and the cohort. Increasing time to blood draw significantly and independently increased the risk of WTC-LI. Conclusions Elevated serum levels of MMP-3 and MMP-12 reduce the risk of developing WTC-LI. At any level of MMP-3 or 12, increased time to blood draw is associated with a diminished protective effect.
Subject:
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Adult
Case-Control Studies
Firefighters
Forced Expiratory Volume
Gene Expression
Humans
Logistic Models
Lung
Lung Injury
Male
Matrix Metalloproteinase 3
Matrix Metalloproteinase 12
Middle Aged
Occupational Exposure
Prognosis
September 11 Terrorist Attacks
Time Factors

Source:
PLoS One. 2013 ; 8(10).;
Pubmed ID:
24146820
Pubmed Central ID:
PMC3797818
Document Type:
Journal Article ;
Funding:
K24A1080298/PHS HHS/United States ; NIEHST32ES007267/ES/NIEHS NIH HHS/United States ; NIH-NHLBI K23HL084191/PHS HHS/United States ; NIH-R01HL057879/HL/NHLBI NIH HHS/United States ; U10-OH008242/OH/NIOSH CDC HHS/United States ; ... More +
K24A1080298/PHS HHS/United States ; NIEHST32ES007267/ES/NIEHS NIH HHS/United States ; NIH-NHLBI K23HL084191/PHS HHS/United States ; NIH-R01HL057879/HL/NHLBI NIH HHS/United States ; U10-OH008242/OH/NIOSH CDC HHS/United States ; U10-OH008243/OH/NIOSH CDC HHS/United States ; UL1RR029893/RR/NCRR NIH HHS/United States ; Less -
Place as Subject:
New York City, NY ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:00b8e3309350e5e7b8606e2eaaf495ed173ba4e4b41677935ce7c72d85d9b60a
File Type:

Supporting Files

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