Effect of Manganese Treatment on the Accumulation on Biologically Relevant Metals in Rat Cochlea and Brain by Inductively Coupled Plasma Mass Spectrometry

Details

• Personal Author:
  Aga DS ; Ding D ; Krishnan Muthaiah VP ; Manohar S ; Mullin EJ ; Roth JA ; Salvi R ; Wegst-Uhrich SR
• Description:
  Manganese (Mn), iron (Fe), zinc (Zn), and copper (Cu) are essential transitions metals that are required in trace amounts, however chronic exposure to high concentrations can cause severe and irreversible neurotoxicity. Since prolonged exposure to Mn leads to manganism, a disorder exhibiting a diverse array of neurological impairments progressing to a debilitating and irreversible extrapyramidal condition symptomatically similar to Parkinson's disease, we measured the concentration of Mn as well as Fe, Zn and Cu in three region of the brain (globus pallidus, striatum and inferior colliculus) and three regions in the cochlea (stria vascularis, basilar membrane and modiolus) under normal conditions or after 30 or 60 days of oral administration of Mn (10 mg/ml ad libitum). Under normal conditions, Mn, Zn and Fe were typically higher in the cochlea than in the three brain regions whereas Cu was equal to or lower. Oral treatment with Mn for 30 or 60 days resulted in 20-75 % increases in Mn concentrations in both cochlea and brain samples, but had little effect on Cu and Fe levels. In contrast, Zn levels decreased (20-80 %) with Mn exposure. Our results show for the first time how prolonged oral Mn-ingestion affects the concentration of Mn, Cu, Zn and Fe, in the three regions of the cochlea, the inferior colliculus in auditory midbrain and the striatum and globus pallidus, two regions implicated in Parkinson's disorder. The Mn-induced changes in the concentration of Mn, Cu, Zn and Fe may provide new insights relevant to the neurotoxicity of Mn and the transport and accumulation of these metals in cochlea and brain. [Description provided by NIOSH]
• Subjects:
  Animals Copper Ferrous Compounds Manganese Metals Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Animal Studies Author Keywords: Cochlea Ear Disorders ICP-MS Iron Neurological Disorders Neurotoxic Effects Neurotoxicity Trace Analysis Trace Metals Transition Metals Zinc

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• ISSN:
  0966-0844
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Illinois ; New York ; OSHA Region 2 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  6
• NIOSHTIC Number:
  nn:20062288
• Citation:
  BioMetals 2015 Dec; 28(6):1009-1016
• Contact Point Address:
  Jerome A. Roth, Department of Pharmacology and Toxicology, University at Buffalo, 11 Cary Hall, Buffalo, NY, 14214, USA
• Email:
  jaroth@buffalo.edu
• CAS Registry Number:
  Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6) ; Manganese (CAS RN 7439-96-5) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2016
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  University of Illinois at Chicago
• Peer Reviewed:
  True
• Start Date:
  20120701
• Source Full Name:
  BioMetals
• End Date:
  20140630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fee65302c85a3936560fe208ccdefbb8ba18fbabeaf173eb8f79de499b0db7258113ddb75a3feb07069eafc779c584ba88aa303f90c5af7386c255af86197b48
• Download URL:
  https://stacks.cdc.gov/view/cdc/225568/cdc_225568_DS1.pdf
• File Type:
  [PDF - 638.38 KB ]