Details:

Alternative Title:
Infect Dis Obstet Gynecol
Publisher's site:
http://dx.doi.org/10.1155/2013/340702
Personal Author:
Dow, Anna ; Kayira, Dumbani ; Hudgens, Michael G. ; Van Rie, Annelies ; King, Caroline C. ; ... More +
Dow, Anna ; Kayira, Dumbani ; Hudgens, Michael G. ; Van Rie, Annelies ; King, Caroline C. ; Ellington, Sascha ; Chome, Nelecy ; Kourtis, Athena ; Turner, Abigail Norris ; Kacheche, Zebrone ; Jamieson, Denise J. ; Chasela, Charles ; van der Horst, Charles Less -
Description:
Limited data exist on cotrimoxazole prophylactic treatment (CPT) in pregnant women, including protection against malaria versus standard intermittent preventive therapy with sulfadoxine-pyrimethamine (IPTp).|Using observational data we examined the effect of CPT in HIV-infected pregnant women on malaria during pregnancy, low birth weight and preterm birth using proportional hazards, logistic, and log binomial regression, respectively. We used linear regression to assess effect of CPT on CD4 count.|Data from 468 CPT-exposed and 768 CPT-unexposed women were analyzed. CPT was associated with protection against malaria versus IPTp (hazard ratio: 0.35, 95% Confidence Interval (CI): 0.20, 0.60). After adjustment for time period this effect was not statistically significant (adjusted hazard ratio: 0.66, 95% CI: 0.28, 1.52). Among women receiving and not receiving CPT, rates of low birth weight (7.1% versus 7.6%) and preterm birth (23.5% versus 23.6%) were similar. CPT was associated with lower CD4 counts 24 weeks postpartum in women receiving (-77.6 cells/ μ L, 95% CI: -125.2, -30.1) and not receiving antiretrovirals (-33.7 cells/ μ L, 95% CI: -58.6, -8.8).|Compared to IPTp, CPT provided comparable protection against malaria in HIV-infected pregnant women and against preterm birth or low birth weight. Possible implications of CPT-associated lower CD4 postpartum warrant further examination.
Subject:
[+]
Adult
AIDS-Related Opportunistic Infections
Antimalarials
CD4 Lymphocyte Count
Female
HIV Infections
Humans
Infant, Low Birth Weight
Malaria
Pregnancy
Pregnancy Complications, Infectious
Pregnancy Outcome
Premature Birth
Regression Analysis
Trimethoprim-Sulfamethoxazole Combination
Young Adult

Source:
Infect Dis Obstet Gynecol. 2013; 2013.
Pubmed ID:
24363547
Pubmed Central ID:
PMC3865641
Document Type:
Journal Article
Funding:
13-01 U48-CCU409660-09/PHS HHS/United States ; 2-D43 TW01039-06/TW/FIC NIH HHS/United States ; 22-09 U48-DP001944-01/DP/NCCDPHP CDC HHS/United States ; 26-04 U48-DP000059-01/DP/NCCDPHP CDC HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; ... More +
13-01 U48-CCU409660-09/PHS HHS/United States ; 2-D43 TW01039-06/TW/FIC NIH HHS/United States ; 22-09 U48-DP001944-01/DP/NCCDPHP CDC HHS/United States ; 26-04 U48-DP000059-01/DP/NCCDPHP CDC HHS/United States ; P30 AI050410/AI/NIAID NIH HHS/United States ; P30-AI50410/AI/NIAID NIH HHS/United States Less -
Place as Subject:
Malawi
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:0cea6e3667f488536e6f1031347cdc149a2a6825e127a7ba4d14505e93bb9b10
File Type:

Supporting Files

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