Combining Three Cohorts of World Trade Center Rescue/Recovery Workers for Assessing Cancer Incidence and Mortality

Details

• Personal Author:
  Boffetta P ; Brackbill RM ; Cone, James E. ; Dasaro CR ; Farfel MR ; Goldfarb DG ; Hall CB ; Kahn AR ; Kristjansson D ; Li J ; Luccini RG ; Prezant DJ ; Qiao B ; Schymura MJ ; Skerker M ; Solomon A ; Todd AC ; Walker DJ ; Webber MP ; Yung J ; Zeig-Owens R
• Description:
  Three cohorts including the Fire Department of the City of New York (FDNY), the World Trade Center Health Registry (WTCHR), and the General Responder Cohort (GRC), each funded by the World Trade Center Health Program have reported associations between WTC-exposures and cancer. Results have generally been consistent with effect estimates for excess incidence for all cancers ranging from 6 to 14% above background rates. Pooling would increase sample size and de-duplicate cases between the cohorts. However, pooling required time consuming steps: obtaining Institutional Review Board (IRB) approvals and legal agreements from entities involved; establishing an honest broker for managing the data; de-duplicating the pooled cohort files; applying to State Cancer Registries (SCRs) for matched cancer cases; and finalizing analysis data files. Obtaining SCR data use agreements ranged from 6.5 to 114.5 weeks with six states requiring >20 weeks. Records from FDNY (n = 16,221), WTCHR (n = 29,372), and GRC (n = 33,427) were combined de-duplicated resulting in 69,102 unique individuals. Overall, 7894 cancer tumors were matched to the pooled cohort, increasing the number cancers by as much as 58% compared to previous analyses. Pooling resulted in a coherent resource for future research for studies on rare cancers and mortality, with more representative of occupations and WTC- exposure. [Description provided by NIOSH]
• Subjects:
  Cohort Studies Emergency Responders Environmental Exposure Firefighters Health Care Facilities Workforce And Services Mortality Occupational Health Safety September 11 Terrorist Attacks
• Keywords:
  Author Keywords: World Trade Center Cancer Cancer Registries Cohort Studies Disaster Clean-up Emergency Responders Environmental Exposure Exposure Fire Fighters First Responders Medical Monitoring Mortality Data Pooling Cohorts Rescue And Recovery Workers Rescue Workers Surveillance Programs World Trade Center WTC

  More +
• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  4
• NIOSHTIC Number:
  nn:20062012
• Citation:
  Int J Environ Res Public Health 2021 Feb; 18(4):1386
• Contact Point Address:
  Robert M. Brackbill, World Trade Center Health Registry, New York City Department of Health and Mental Hygiene, Long Island City, NY 11101, USA
• Email:
  rbrackbi@health.nyc.gov
• Federal Fiscal Year:
  2021
• Performing Organization:
  Albert Einstein College of Medicine, Inc., Bronx, New York
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:2e03fdd9309e277da9ee815070080f83f1751925253337439b14bbeb411f7b5d7b09a63ddf9ef74969f47ad4d4e2f1ce3cce26973c7f2865c5480988a6518a17
• Download URL:
  https://stacks.cdc.gov/view/cdc/225338/cdc_225338_DS1.pdf
• File Type:
  [PDF - 574.57 KB ]