A Case Report of Adult Lead Toxicity Following Use of Ayurvedic Herbal Medication

Details

• Personal Author:
  Breeher L ; Fuortes L ; Gerr F
• Description:
  Introduction: Ayurvedic medications consist of herbs that may be intentionally combined with metals, such as lead, mercury, iron, and zinc. Ayurvedic practitioners and their patients believe that the toxic properties of the metals are reduced or eliminated during preparation and processing. Case report: A 69 year old Caucasian male retired professional with a prior history of stroke presented for evaluation of new onset depression, fatigue, generalized weakness, constipation, anorexia, and weight loss. History revealed that his symptoms were temporally related to initiation of an Ayurvedic herbal medication. The patient had been previously admitted to another hospital for these symptoms and was found to have a severe anemia for which no etiology was found. Laboratory tests revealed an elevated blood lead level and a diagnosis of symptomatic lead toxicity was made. The patient was treated with intramuscular, intravenous, and oral chelation therapy to promote lead excretion. Because of complaints of continued poor mental function, neuropsychological tests were administered before and after one of the chelation treatments and showed improvement in measures of attention and other cognitive domains. In addition, the patient was able to discontinue use of antidepressant medication after chelation. Discussion: A high index of suspicion of metal toxicity is necessary among persons with characteristic symptoms and signs in the absence of occupational exposure. Despite limited evidence for chelation in adults and in those with modest blood lead levels, this patient appeared to benefit from repeated chelation therapy. Both allopathic and alternative medicine practitioners and public health specialists need to be aware of the potential for contamination of and side effects from alternative pharmacologic and herbal therapies. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Health Personnel Lead Lead Poisoning Metals Nervous System Occupational Health Poisoning Safety
• Keywords:
  Author Keywords: Lead Poisoning Ayurvedic Medicine Blood Lead Levels Case Reports Chelating Agents Chelation Clinical Toxicity Cognitive Function Health Care Personnel Lead Compounds Lead Poisoning Medicinal Chemicals Mental Processes Metal Compounds Pharmacology Plants Therapeutic Agents Toxic Materials

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• ISSN:
  1745-6673
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Minnesota ; OSHA Region 5 ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  26
• Volume:
  8
• NIOSHTIC Number:
  nn:20061986
• Citation:
  J Occup Med Toxicol 2013 Oct; 8:26
• Contact Point Address:
  Laurence Fuortes, Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, 105 River Street, Iowa City, IA 52242, USA
• Email:
  laurence-fuortes@uiowa.edu
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2014
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational Medicine and Toxicology
• End Date:
  20290630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d6d8814b5e429e5af151d7f71e1fb7ff0b108ebd3689082f80879f99b19161c7b095c6d0818d4b948a3466283fd348b9a76a6035db3c7417a706d8a3038bf6ec
• Download URL:
  https://stacks.cdc.gov/view/cdc/225314/cdc_225314_DS1.pdf
• File Type:
  [PDF - 234.03 KB ]