Occupational Use of High-Level Disinfectants and Asthma Incidence in Early- to Mid-Career Female Nurses: A Prospective Cohort Study

Details

• Personal Author:
  Boggs KM ; Carmago CA Jr. ; Chavarro JE ; Dumas O ; Gaskins AJ ; Henn SA ; Le Moual N ; Varraso R
• Description:
  Objectives: Occupational use of disinfectants among healthcare workers has been associated with asthma. However, most studies are cross-sectional, and longitudinal studies are not entirely consistent. To limit the healthy worker effect, it is important to conduct studies among early- to mid-career workers. We investigated the prospective association between use of disinfectants and asthma incidence in a large cohort of early- to mid-career female nurses. Methods: The Nurses' Health Study 3 is an ongoing, prospective, internet-based cohort of female nurses in the USA and Canada (2010-present). Analyses included 17 280 participants without a history of asthma at study entry (mean age: 34 years) and who had completed ≥1 follow-up questionnaire (sent every 6 months). Occupational use of high-level disinfectants (HLDs) was evaluated by questionnaire. We examined the association between HLD use and asthma development, adjusted for age, race, ethnicity, smoking status and body mass index. Results: During 67?392 person-years of follow-up, 391 nurses reported incident clinician-diagnosed asthma. Compared with nurses who reported <=5 years of HLD use (89%), those with >5 years of HLD use (11%) had increased risk of incident asthma (adjusted HR (95% CI), 1.39 (1.04 to 1.86)). The risk of incident asthma was elevated but not statistically significant in those reporting >5 years of HLD use and current use of >=2 products (1.72 (0.88 to 3.34)); asthma risk was significantly elevated in women with >5 years of HLD use but no current use (1.46 (1.00 to 2.12)). Conclusions: Occupational use of HLDs was prospectively associated with increased asthma incidence in early- to mid-career nurses. [Description provided by NIOSH]
• Subjects:
  Aging Asthma Asthma, Occupational Cohort Studies Disinfectants Health Personnel Occupational Health Race Factors Safety Smokers Surveys And Questionnaires Women

  More +
• Keywords:
  Age Groups BMI Body Mass Index Cohort Studies Nurses Questionnaires Racial Factors Smoking
• ISSN:
  1351-0711
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DFSE - Division of Field Studies and Engineering
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  244-247
• Volume:
  78
• Issue:
  4
• NIOSHTIC Number:
  nn:20061872
• Citation:
  Occup Environ Med 2021 Apr; 78(4):244-247
• Contact Point Address:
  Dr Orianne Dumas, Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Équipe d'Épidémiologie respiratoire intégrative, CESP, INSERM, Villejuif 94807, France
• Email:
  orianne.dumas@inserm.fr
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Services ; Transportation, Warehousing and Utilities
• Performing Organization:
  Brigham and Women's Hospital, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  20130901
• Source Full Name:
  Occupational and Environmental Medicine
• End Date:
  20170831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3854489326bd7a273aad6c2cb9ed53d92d97e92351cd110f402bf5b54814f1bb7d3134c029aed41fd457a11088964d7d729a67cce9cdf56dd8dbf29ee64443a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/225226/cdc_225226_DS1.pdf
• File Type:
  [PDF - 243.39 KB ]