Multistate Study of the Epidemiology of Clubfoot

Details

• Personal Author:
  Hashmi SS ; Mai CT ; Marengo L ; Meyer RE ; Olney RS ; Parker SE ; Rickard R ; Strickland MJ ; Wang Y
• Corporate Authors:
  National Birth Defects Prevention Network
• Description:
  BACKGROUND: Although clubfoot is a common birth defect, with a prevalence of approximately 1 per 1000 livebirths, the etiology of clubfoot remains largely unknown. Studies of the prevalence and risk factors for clubfoot in the United States have previously been limited to specific states. The purpose of this study was to pool data from several birth defects surveillance programs to better estimate the prevalence of clubfoot and investigate its risk factors. METHODS: The 10 population-based birth defects surveillance programs that participated in this study ascertained 6139 cases of clubfoot from 2001 through 2005. A random sample of 10 controls per case, matched on year and state of birth, was selected from birth certificates. Data on infant and maternal risk factors were collected from birth certificates. Prevalence was calculated by pooling the state-specific data. Conditional logistic regression was used to investigate the association between risk factors and clubfoot. RESULTS: The overall prevalence of clubfoot was 1.29 per 1000 livebirths; 1.38 among non-Hispanic whites, 1.30 among Hispanics, and 1.14 among non-Hispanic blacks or African Americans. Maternal age, parity, education, and marital status were significantly associated with clubfoot. Maternal smoking and diabetes also showed significant associations. Several of these observed associations were consistent between surveillance programs. CONCLUSIONS: We estimated the prevalence of clubfoot using data from several birth defects programs, representing one-quarter of all births in the United States. Our findings underline the importance of birth defects surveillance programs and their utility in monitoring population-based prevalence and investigating risk factors. [Description provided by NIOSH]
• Subjects:
  Epidemiology Occupational Health Pregnancy Public Health Risk Assessment Risk Factors Safety
• Keywords:
  Author Keywords: Clubfoot Birth Defects Birth Defects Surveillance Foot Disorders Population Based Studies Public Health Risk Factors Surveillance Talipes Equinovarus
• ISSN:
  1542-0752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Georgia ; New York ; North Carolina ; OSHA Region 2 ; OSHA Region 4 ; OSHA Region 6 ; OSHA Region 8 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  85
• Issue:
  11
• NIOSHTIC Number:
  nn:20061831
• Citation:
  Birth Defects Res A Clin Mol Teratol 2009 Nov; 85(11):897-904
• Contact Point Address:
  Samantha Parker, MSPH, 1600 Clifton Rd, MS-E86, Atlanta, GA 30333
• Email:
  gwf5@cdc.gov
• Federal Fiscal Year:
  2010
• Performing Organization:
  Emory University, Atlanta
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Birth Defects Research Part A: Clinical and Molecular Teratology
• End Date:
  20180630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3758cc94f85b05536d65e591b18c8b97237f855bb165772b2f84b7af4992bce76b28d35532c9b7690e9f2cda5787486b61cf6166e99fa8962c80efffdf7e7569
• Download URL:
  https://stacks.cdc.gov/view/cdc/225203/cdc_225203_DS1.pdf
• File Type:
  [PDF - 147.96 KB ]