Double Gloving of Disposable Nitrile Gloves Exposed to Diethylene Glycol Mono-N-Butyl Ether

Details

• Personal Author:
  Que Hee S ; Takaku-Pugh S
• Description:
  Double gloving of disposable gloves is now commonplace in healthcare settings when extra protection is needed against aqueous solutions and especially for antineoplastic drugs in isotonic aqueous media. In the present study, an ASTM F739 2.54cm cell with closed-loop water collection without recirculation at 35 degrees C in a moving tray water bath was used to test the permeation of diethylene glycol mono-n-butyl ether (DGBE) through four types of disposable nitrile gloves that were singly and doubly layered in the permeation cell. Samples were taken over 8hr for capillary gas chromatograph-mass spectrometer quantitation. The breakthrough time (tn) at a permeation of 250ng/cm2 increased as thickness increased for single layers, but the steady-state permeation rates Ps in ug/cm2/min did not always decrease with increasing thickness. The double-layer tn, Ps and thickness were also more variable relative to a single layer. The thinnest glove with 80 um thickness showed a tn = 0-5 min whereas its double layer was 15-20 min. The thickest glove of 132 um exhibited a tn = 10-15 min but its double layer was tn = 45-55 min. The adjusted double-layer average tn divided by the adjusted single-layer average tn was 4.0 +/- 0.8. The adjusted average single-layer Ps divided by the adjusted average double-layer Ps was 3.5 +/- 0.8. Other results showed that the average glove swelling was <10%; microscopic and leak testing indicated no penetration and reflectance infrared analysis also showed no chemical changes on the inside glove surfaces. Thus, the permeations were adjudged to obey Fick's First Law of Diffusion to allow calculation of diffusion coefficients D in cm2/min. The average single-layer D divided by the average double-layer D was 1.3 +/- 0.2. Double gloving in the field is therefore also probably more protective than single gloving against DGBE for the four types of disposable nitrile gloves tested. [Description provided by NIOSH]
• Subjects:
  Nitriles Occupational Health Personal Protective Equipment Protective Clothing Safety
• Keywords:
  Author Keywords: Breakthrough Time Diethylene Glycol Mono-nbutyl Ether Disposable Nitrile Gloves Double Gloving Equipment Testing Gloves Hand Protection Permeation Personal Protective Equipment PPE Protective Materials

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• ISSN:
  1545-9624
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  334-342
• Volume:
  17
• Issue:
  7
• NIOSHTIC Number:
  nn:20061820
• Citation:
  J Occup Environ Hyg 2020 Jul-Aug; 17(7-8):334-342
• Contact Point Address:
  Shane Que Hee, Department of Environmental Health Sciences, UCLA Center for Occupational and Environmental Health, Fielding School of Public Health, 650 Charles Young Jr Drive S, Los Angeles, CA 90095-1772, USA
• Email:
  squeehee@ucvla,edu
• CAS Registry Number:
  Diethylene glycol monobutyl ether (CAS RN 112-34-5)
• Federal Fiscal Year:
  2020
• Performing Organization:
  University of California, Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20090901
• Source Full Name:
  Journal of Occupational and Environmental Hygiene
• End Date:
  20130831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:353467d91730bd0cd04998db13428f86c04ac5b304095f5599aa12e2b6051145743a99746168d52b5047177f27c73226a4b1ca7fe62684ca02a4e36e520bffe6
• Download URL:
  https://stacks.cdc.gov/view/cdc/225193/cdc_225193_DS1.pdf
• File Type:
  [PDF - 1.09 MB ]