Factors Contributing to Sex Differences in Mice Inhaling Aspergillus fumigatus

Details

• Personal Author:
  Ceesay M ; Leier JA ; Pandey S ; Schaefer AL ; Tesch J ; Wisenden BD
• Description:
  Aspergillus fumigatus is a respiratory fungal pathogen and an allergen, commonly detected in flooded indoor environments and agricultural settings. Previous studies in Balb/c mice showed that repeated inhalation of live and dry A. fumigatus spores, without any adjuvant, elevated allergic immune response and airway remodeling. Sex-specific differences can influence host-pathogen interactions and allergic-asthma related outcomes. However, the effect of host sex on immune response, in the context of A. fumigatus exposure, remains unknown. In this study, we quantified the multivariate and univariate immune response of C57BL/6J mice to live, dry airborne A. fumigatus spores. Our results corroborate previous results in Balb/c mice that repeated inhalation of live A. fumigatus spores is suffcient to induce mucus production and inflammation by day 3 post last challenge, and antibody titers and collagen production by day 28 post-challenge. Principal Component Analysis (PCA) showed that females exhibited significantly higher levels of immune components than males did. Taken together, our data indicate that host-sex is an important factor in shaping the immune response against A. fumigatus, and must be considered when modeling disease in animals, in designing diagnostics and therapeutics for A. fumigatus-associated diseases or while drafting evidence-based guidelines for safe mold levels. [Description provided by NIOSH]
• Subjects:
  Antibodies Fungi Hypersensitivity Immune System Laboratories Occupational Health Respiratory System Safety Sex Characteristics
• Keywords:
  Allergens Allergic Reactions Antibody Response Aspergillus Infection Author Keywords: Airway Remodeling Collagen Exposure Assessment Fungal Infections IgE Immune Reaction Immunoglobulins Inhalation Inhalation Studies Laboratory Animals Models Molds Mucus Pathogens Principal Component Analysis Proteins Sex Factors

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• ISSN:
  1660-4601
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Colorado ; Minnesota ; OSHA Region 5 ; OSHA Region 8
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  23
• NIOSHTIC Number:
  nn:20061564
• Citation:
  Int J Environ Res Public Health 2020 Dec; 17(23):8851
• Contact Point Address:
  Sumali Pandey, Biosciences Department, Minnesota State University Moorhead, Moorhead, 56563 MN, USA
• Email:
  sumali.pandey@mnstate.edu
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  Colorado State University - Ft. Collins
• Peer Reviewed:
  True
• Start Date:
  20030915
• Source Full Name:
  International Journal of Environmental Research and Public Health
• End Date:
  20270914
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:25085a9fce6fd475a2cd43053b6394c34ca674e576658e575cee107ec857127e7b66412198539dab82843589b041316fece06a49c2bd261ba35a26cd6947ad45
• Download URL:
  https://stacks.cdc.gov/view/cdc/225068/cdc_225068_DS1.pdf
• File Type:
  [PDF - 3.75 MB ]