Details:

Alternative Title:
Infect Dis Obstet Gynecol
Publisher's site:
http://dx.doi.org/10.1155/2013/784718
Personal Author:
Kim, Suk Chul ; Messing, Susan ; Shah, Krupa ; Luque, Amneris E.
Kim, Suk Chul ; Messing, Susan ; Shah, Krupa ; Luque, Amneris E. Less -
Description:
More HIV-infected women are reaching older age and menopause, but there is limited information on cervical squamous intraepithelial lesions (SILs) on these women.|To assess the effect of HAART and menopause on SILs in HIV-infected women, we reviewed the results of Papanicolaou (Pap) tests obtained between 1991 and 2011 on 245 women. Progression to SILs was determined by comparing Pap test results. The association of HAART and transition to menopause on SILs was assessed using survival analysis.|Women receiving HAART had a 52% reduced risk in the progression to SILs compared to women receiving any other antiretroviral regimen or no regimen (CI: 0.33-0.70, P = 0.0001). A greater increase of CD4(+) cell counts was associated with a greater reduction on the risk of progression to SILs. Menopausal women had a 70% higher risk of progression to SILs than premenopausal women (CI: 1.11-2.62, P < 0.0001), adjusting for HIV medications, CD4(+) count, duration of HIV infection, moderation effect of menopause by age, prior IV drug use, and smoking.|HAART had a positive long-term effect on the progression to SILs. However, being younger and menopausal increases the risk of progression.
Subject:
[+]
Adult
Age Factors
AIDS-Related Opportunistic Infections
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Cervical Intraepithelial Neoplasia
Disease Progression
Female
HIV Infections
Humans
Menopause
Middle Aged
Papillomavirus Infections
Research Article
Risk Factors
Uterine Cervical Neoplasms

Source:
Infect Dis Obstet Gynecol. 2013; 2013.
Pubmed ID:
24453469
Pubmed Central ID:
PMC3878554
Document Type:
Journal Article
Funding:
P30 AI078498/AI/NIAID NIH HHS/United States ; UL1 PR024160/PR/OCPHP CDC HHS/United States
P30 AI078498/AI/NIAID NIH HHS/United States ; UL1 PR024160/PR/OCPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fa33e0ff5361e5c2c6cae52e35b818847891b24e39902664e19b6da86f30a3a0
File Type:

Supporting Files

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