Details:

Alternative Title:
Infect Dis Obstet Gynecol
Personal Author:
Kim, Suk Chul ; Messing, Susan ; Shah, Krupa ; Luque, Amneris E.
Kim, Suk Chul ; Messing, Susan ; Shah, Krupa ; Luque, Amneris E. Less -
Description:
More HIV-infected women are reaching older age and menopause, but there is limited information on cervical squamous intraepithelial lesions (SILs) on these women.|To assess the effect of HAART and menopause on SILs in HIV-infected women, we reviewed the results of Papanicolaou (Pap) tests obtained between 1991 and 2011 on 245 women. Progression to SILs was determined by comparing Pap test results. The association of HAART and transition to menopause on SILs was assessed using survival analysis.|Women receiving HAART had a 52% reduced risk in the progression to SILs compared to women receiving any other antiretroviral regimen or no regimen (CI: 0.33-0.70, P = 0.0001). A greater increase of CD4(+) cell counts was associated with a greater reduction on the risk of progression to SILs. Menopausal women had a 70% higher risk of progression to SILs than premenopausal women (CI: 1.11-2.62, P < 0.0001), adjusting for HIV medications, CD4(+) count, duration of HIV infection, moderation effect of menopause by age, prior IV drug use, and smoking.|HAART had a positive long-term effect on the progression to SILs. However, being younger and menopausal increases the risk of progression.
Subjects:
[+]
Adult Age Factors AIDS-Related Opportunistic Infections Antiretroviral Therapy, Highly Active CD4 Lymphocyte Count Cervical Intraepithelial Neoplasia Disease Progression Female HIV Infections Humans Menopause Middle Aged Papillomavirus Infections Risk Factors Uterine Cervical Neoplasms
Source:
Infect Dis Obstet Gynecol. 2013; 2013.
Pubmed ID:
24453469
Pubmed Central ID:
PMC3878554
Document Type:
Journal Article
Funding:
P30 AI078498/AI/NIAID NIH HHS/United States ; UL1 PR024160/PR/OCPHP CDC HHS/United States
P30 AI078498/AI/NIAID NIH HHS/United States ; UL1 PR024160/PR/OCPHP CDC HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:fa33e0ff5361e5c2c6cae52e35b818847891b24e39902664e19b6da86f30a3a0
Download URL:
https://stacks.cdc.gov/view/cdc/22482/cdc_22482_DS1.pdf
File Type:

Supporting Files

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