Tumorigenic Response in Lung Tumor Susceptible A/J Mice After Sub-Chronic Exposure to Calcium Chromate or Iron (III) Oxide

Details

• Personal Author:
  Antonini JM ; Battelli LA ; Erdely A ; Falcone LM ; Fraser K ; Friend S ; Grose L ; Kashon ML ; Salmen R ; Trainor T ; Yang C ; Zeidler-Erdely PC
• Description:
  Iron oxides are Group 3 (not classifiable as to its carcinogenicity to humans) according to the International Agency for Research on Cancer (IARC). Occupational exposures during iron and steel founding and hematite underground mining as well as other iron predominant exposures such as welding are Group 1 (carcinogenic to humans). The objective of this study was to investigate the potential of iron as iron (III) oxide (Fe2O3) to initiate lung tumors in A/J mice, a lung tumor susceptible strain. Male A/J mice were exposed by oropharyngeal aspiration to suspensions of Fe2O3 (1 mg) or calcium chromate (CaCrO4; 100 µg; positive control) for 26 weeks (once per week). Shams were exposed to 50 µL phosphate buffered saline (PBS; vehicle). Mice were euthanized 70 weeks after the first exposure and lung nodules were enumerated. Both CaCrO4 and Fe2O3 significantly increased gross-observed lung tumor multiplicity in A/J mice (9.63 +/- 0.55 and 3.35 +/- 0.30, respectively) compared to sham (2.31 +/- 0.19). Histopathological analysis showed that bronchiolo-alveolar adenomas (BAA) and carcinomas (BAC) were the primary lung tumor types in all groups and were increased in the exposed groups compared to sham. BAC were significantly increased (146 %) in the CaCrO4 group and neared significance in the Fe2O3 group (100 % increase; p = 0.085). BAA and other histopathological indices of toxicity followed the same pattern with exposed groups increased compared to sham control. In conclusion, evidence from this study, in combination with our previous studies, demonstrate that exposure to iron alone may be a potential risk factor for lung carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Carcinogens Chromates Ferrous Compounds Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Welding

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• Keywords:
  Adenocarcinomas Alveolar Cells Author Keywords: Welding Fumes Calcium Compounds Carcinogenesis Exposure Assessment Histopathology Iron Iron Oxides Laboratory Animals Lung Disorders Metal Fumes Metal Oxides Strain A Tumorigenesis Welding Fumes

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• ISSN:
  0378-4274
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  60-65
• Volume:
  334
• NIOSHTIC Number:
  nn:20061096
• Citation:
  Toxicol Lett 2020 Nov; 334:60-65
• Contact Point Address:
  Patti C. Zeidler-Erdely, National Institutes for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road, Morgantown, WV 26505, United States.
• Email:
  paz9@cdc.gov
• CAS Registry Number:
  Calcium chromate (CAS RN 13765-19-0) ; Iron oxide (Fe2O3) (CAS RN 1309-37-1)
• Federal Fiscal Year:
  2021
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  Toxicology Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:94167461a0d9af41b32e3a23e6593e2d48167626c43fa225ac42bd1e0d381d5770722e52344f79dfe5044b1297682bbe031e7a6d100213c01b5224efc3f1db05
• Download URL:
  https://stacks.cdc.gov/view/cdc/224765/cdc_224765_DS1.pdf
• File Type:
  [PDF - 2.88 MB ]