A Prospective Study of Weight Gain in Women Diagnosed with Early-Stage Invasive Breast Cancer, Ductal Carcinoma In Situ, and Women Without Breast Cancer

Details

• Personal Author:
  Ekenga CC ; Jeffe DB ; Perez M ; Schootman M ; Wang X
• Description:
  Background: Weight gain after breast cancer has been associated with recurrence and mortality. We therefore examined factors associated with =5% weight gain over 2-year follow-up of a cohort of newly diagnosed early-stage invasive breast cancer (EIBC) and ductal carcinoma in situ (DCIS) patients and age-matched controls without a breast cancer history. Materials and Methods: We interviewed participants 4-6 weeks after definitive surgical treatment (patients) or a negative/benign screening mammogram (controls). Multivariable logistic regression models were used to identify socioeconomic, psychosocial, and treatment factors associated with =5% weight gain over 2-year follow-up. Results: Overall, 88 (24%) of 362 EIBC patients, 31 (17%) of 178 DCIS patients, and 82 (15%) of 541 controls had =5% weight gain during follow-up. EIBC patients were more likely to experience =5% weight gain than DCIS patients (Odds ratio [OR] = 2.16; 95% confidence interval [95% CI] = 1.19-3.95) and controls (OR = 1.76; 95% CI = 1.23-2.51). Among EIBC patients, older patients (OR = 0.96; 95% CI = 0.93-0.99), patients who underwent endocrine therapy (OR = 0.43; 95% CI = 0.19-0.95), smokers (OR = 0.35; 95% CI = 0.14-0.86), and African Americans (OR = 0.23; 95% CI = 0.09-0.58) were less likely to have =5% weight gain than their respective counterparts. Among DCIS patients, older patients (OR = 0.94; 95% CI = 0.89-0.99) were less likely to have =5% weight gain. Among controls, smokers were more likely to have =5% weight gain (OR = 3.03; 95% CI = 1.49-6.17). Conclusions: EIBC patients were more likely than DCIS patients and controls to experience =5% weight gain over follow-up. Studies are necessary to elucidate mechanisms of weight gain in early-stage breast cancer survivors. [Description provided by NIOSH]
• Subjects:
  Aging Carcinogens Estrogens Mental Health Neoplasms Occupational Health Race Factors Safety Smokers Women
• Keywords:
  Age Groups Author Keywords: Breast Cancer BMI Body Mass Index Breast Cancer Cancer DCIS Ductal Carcinoma In Situ Early-stage Breast Cancer EIBC Endocrine Function Estrogen Receptor Humans Models Psychology Psychosocial Factors Racial Factors Regression Analysis Smoking Socioeconomics Statistical Analysis Total Worker Health TWH Weight Factors Weight Gain

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• ISSN:
  1059-7115
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Iowa ; Missouri ; OSHA Region 7
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• Issue:
  4
• NIOSHTIC Number:
  nn:20061088
• Citation:
  J Women's Health 2020 Apr; 29(4):524-533
• Contact Point Address:
  Christine C. Ekenga, PhD, MPH, Brown School, Washington University in St. Louis, Campus Box 1196, One Brookings Drive, St. Louis, MO 63130
• Email:
  ekengac@wustl.edu
• Federal Fiscal Year:
  2020
• NORA Priority Area:
  Construction ; Services
• Performing Organization:
  University of Iowa
• Peer Reviewed:
  True
• Start Date:
  20060901
• Source Full Name:
  Journal of Women's Health
• End Date:
  20260831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4b61ec75baac05e75ebc5034edcafeb55b13776d2e7210d96c2bde975a8532c41369d7b8b17cb478cce9b94d3bcb831dc516e8c65ef460bd57067a0a12fddf1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/224758/cdc_224758_DS1.pdf
• File Type:
  [PDF - 199.80 KB ]