The Effect of Psoralens on Hepatic and Cutaneous Drug Metabolizing Enzymes and Cytochrome P-450

Details

• Personal Author:
  Bickers DR ; Molica SJ Jr. ; Mukhtar H ; Pathak MA
• Description:
  Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are now widely used in the treatment of several dermatologic diseases. In this study the effect of 3 different psoralens 8-methoxypsoralen (8-MOP), 4,5',8-trimethylpsoralen (TMP) and isopsoralen on hepatic microsomal drug-metabolizing enzymes and cytochrome P-450 has been assessed in mice and rats. 8-MOP administered orally to CD-1 mice daily for 6 days caused 2-3 fold increases in hepatic aryl hydrocarbon hydroxylase (AHH), ethylmorphine N-demethylase and cytochrome P-450. The absorbance maximum of the induced cytochrome was at 450 nm. Aniline hydroxylase activity was unchanged. Chronic administration of 8-MOP, to hairless mice caused significant enhancement of hepatic ethylmorphine N-demethylase and cytochrome P-450 but had no effect on AHH; whereas chronically administered TMP had no significant effect on any of these parameters. Isopsoralen and TMP administered orally to CD-1 mice daily for 6 days had no effect on any of these liver enzymes or on hepatic drug-metabolizing enzymes and cytochrome P-450 to a lesser extent than do the barbituaes and suggest that this drug could influence the rate of biotransformation of concomitantly administered drugs in patients undergoing PUVA therapy. [Description provided by NIOSH]
• Subjects:
  Animals Enzymes Occupational Health Safety Skin
• Keywords:
  Animal Studies Dermatology Enzymatic Effects Enzyme Activity Liver Microsomes Photosensitivity Ultraviolet Light
• ISSN:
  0022-202X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  201-205
• Volume:
  79
• Issue:
  3
• NIOSHTIC Number:
  nn:20061080
• Citation:
  J Invest Dermatol 1982 Sep; 79(3):201-205
• Contact Point Address:
  David R. Bickers, M.D., Professor and Chairman, Department of Dermatology, Veterans Administration Medical Center, 10701 East Boulevard, Cleveland, OH 44106
• Federal Fiscal Year:
  1982
• Performing Organization:
  Case Western Reserve University, Cleveland, Ohio
• Peer Reviewed:
  True
• Start Date:
  19800929
• Source Full Name:
  Journal of Investigative Dermatology
• End Date:
  19830831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d294994780a397f089e723f697294559413a3a28916d2537ff8556b6880436278c5152201643e7fa3fa0e08ae944135b6044a5c3a4e049e8da4a79a4d988fbe8
• Download URL:
  https://stacks.cdc.gov/view/cdc/224754/cdc_224754_DS1.pdf
• File Type:
  [PDF - 3.53 MB ]