Asthma-COPD Overlap in World Trade Center Health Registry Enrollees, 2015–2016

Details

• Personal Author:
  Cone, James E. ; de la Hoz RE ; Haghighi A ; Li J
• Description:
  Introduction: Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a newly redefined form of chronic airway disease and has not been well studied among 9/11-exposed populations with increased prevalence of asthma. We assessed the prevalence and risk factors associated with ACO in an exposure cohort of World Trade Center Health Registry (WTCHR) enrollees. Methods: This is a longitudinal study, including enrollees with complete data on 9/11/01 exposure at enrollment (2003-2004, Wave 1), asthma and COPD diagnoses and at least 25 years of age at the time of the 2015-2016 (Wave 4) WTCHR survey. Probable ACO was defined as self-reported post-9/11 physician-diagnosed asthma and either emphysema, chronic bronchitis, or COPD. We evaluated whether probable ACO was associated with World Trade Center (WTC)-related exposures, using multivariable logistic regression. Results: Of 36,864 Wave 4 participants, 29,911 were eligible for this analysis, and 1,495 (5.0%) had self-reported post-9/11 probable ACO. After adjusting for demographics and smoking status, we found 38% increased odds of having ACO in enrollees with exposure to the dust cloud, and up to 3.39 times the odds in those with >=3 injuries sustained on 9/11. Among rescue/recovery workers, ever working on the pile, on the pile on 9/11 or 9/12/01, or working on the WTC site for >7 days showed increased odds ratios of having ACO. Conclusion: Probable ACO is associated with WTC exposures. Further study of ACO is needed to understand the development of this and other environmentally or occupationally-related airway diseases, and how to prevent these in disasters like 9/11. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Dust Epidemiology Occupational Health Respiratory System Safety September 11 Terrorist Attacks
• Keywords:
  Airway Obstruction Author Keywords: Epidemiology Chronic Obstructive Pulmonary Disease COPD Dust Exposure Longitudinal Study Phenotypes World Trade Center WTC
• ISSN:
  0277-0903
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  58
• Issue:
  11
• NIOSHTIC Number:
  nn:20060943
• Citation:
  J Asthma 2021 Nov; 58(11):1415-1423
• Contact Point Address:
  James E. Cone, 42-09 28th Street CN6-W, Long Island City, NY 11101, USA
• Email:
  jcone@health.nyc.gov
• Federal Fiscal Year:
  2022
• Performing Organization:
  New York City Health/Mental Hygiene
• Peer Reviewed:
  True
• Start Date:
  20090430
• Source Full Name:
  Journal of Asthma
• End Date:
  20260630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d16245c219f47d27ce5a245f48385021c0d42e45ab80df3988934a9df1c642cb0bbc90976733cfa345f469e2e8e7ea5ea9d1bba25a1ed3202884080a5fc9e27
• Download URL:
  https://stacks.cdc.gov/view/cdc/224685/cdc_224685_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]