Molecular Linkage Between Post-Traumatic Stress Disorder and Cognitive Impairment: A Targeted Proteomics Study of World Trade Center Responders

Details

• Personal Author:
  Bromet E ; Clouston S ; Kotov R ; Kuan P-F ; Luft BJ ; Yang X
• Description:
  Existing work on proteomics has found common biomarkers that are altered in individuals with post-traumatic stress disorder (PTSD) and mild cognitive impairment (MCI). The current study expands our understanding of these biomarkers by profiling 276 plasma proteins with known involvement in neurobiological processes using the Olink Proseek Multiplex Platform in individuals with both PTSD and MCI compared to either disorder alone and with unaffected controls. Participants were World Trade Center (WTC) responders recruited through the Stony Brook WTC Health Program. PTSD and MCI were measured with the PTSD Checklist (PCL) and the Montreal Cognitive Assessment, respectively. Compared with unaffected controls, we identified 16 proteins associated with comorbid PTSD-MCI at P < 0.05 (six at FDR < 0.1), 20 proteins associated with PTSD only (two at FDR < 0.1), and 24 proteins associated with MCI only (one at FDR < 0.1), for a total of 50 proteins. The multiprotein composite score achieved AUCs of 0.84, 0.77, and 0.83 for PTSD-MCI, PTSD only, and MCI only versus unaffected controls, respectively. To our knowledge, the current study is the largest to profile a large set of proteins involved in neurobiological processes. The significant associations across the three case-group analyses suggest that shared biological mechanisms may be involved in the two disorders. If findings from the multiprotein composite score are replicated in independent samples, it has the potential to add a new tool to help classify both PTSD and MCI. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Coal Coal Mining Dust Lung Lung Diseases Mining Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Biological Function Biomarkers Blood Plasma Cognitive Function Emergency Responders First Responders Molecular Biology Neurological System Post-traumatic Stress Disorder Proteins PTSD World Trade Center WTC

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• ISSN:
  2158-3188
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  10
• NIOSHTIC Number:
  nn:20060769
• Citation:
  Transl Psychiatry 2020 Aug; 10:269
• Contact Point Address:
  Benjamin J. Luft, Department of Medicine, Stony Brook University, Stony Brook, NY
• Email:
  Benjamin.luft@stonybrookmedicine.edu
• Federal Fiscal Year:
  2020
• Performing Organization:
  State University of New York at Stony Brook
• Peer Reviewed:
  True
• Start Date:
  20170701
• Source Full Name:
  Translational Psychiatry
• End Date:
  20200630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:eb6c458f91494e6b9f86de58fbec52e6822d0950b4829fea5f37e69b9af66b970bb75979895ba461fcc3d9b348d477ff10962041267fbd51294e450434e5287d
• Download URL:
  https://stacks.cdc.gov/view/cdc/224590/cdc_224590_DS1.pdf
• File Type:
  [PDF - 588.33 KB ]