Transplantation for Work-Related Lung Disease in the USA

Details

• Personal Author:
  Blackley DJ ; Halldin, Cara N. ; Hayanga JWA ; Laney AS
• Description:
  Objectives: Work-related lung diseases (WRLDs) are entirely preventable. To assess the impact of WRLDs on the US transplant system, we identified adult lung transplant recipients with a WRLD diagnosis specified at the time of transplant to describe demographic, payer and clinical characteristics of these patients and to assess post-transplant survival. Methods: Using US registry data from 1991 to 2018, we identified lung transplant recipients with WRLDs including coal workers' pneumoconiosis, silicosis, asbestosis, metal pneumoconiosis and berylliosis. Results: The frequency of WRLD-associated transplants has increased over time. Among 230 lung transplants for WRLD, a majority were performed since 2009; 79 were for coal workers' pneumoconiosis and 78 were for silicosis. Patients with coal workers' pneumoconiosis were predominantly from West Virginia (n=31), Kentucky (n=23) or Virginia (n=10). States with the highest number of patients with silicosis transplant were Pennsylvania (n=12) and West Virginia (n=8). Patients with metal pneumoconiosis and asbestosis had the lowest and highest mean age at transplant (48.8 and 62.1 years). Median post-transplant survival was 8.2 years for patients with asbestosis, 6.6 years for coal workers' pneumoconiosis and 7.8 years for silicosis. Risk of death among patients with silicosis, coal workers' pneumoconiosis and asbestosis did not differ when compared with patients with idiopathic pulmonary fibrosis. Conclusions: Lung transplants for WRLDs are increasingly common, indicating a need for primary prevention and surveillance in high-risk occupations. Collection of patient occupational history by the registry could enhance case identification and inform prevention strategies. [Description provided by NIOSH]
• Subjects:
  Asbestos Coal Coal Mining Demography Inorganic Chemicals Lung Lung Diseases Mining Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Asbestosis Berylliosis Black Lung Disease Coal Miners Coal Workers Pneumoconiosis Demographic Characteristics Lung Disease Lung Disorders Medical Treatment Organs Pneumoconiosis Respiratory System Disorders Silicosis Statistical Analysis Surveillance Treatment

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  RHD - Respiratory Health Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  77
• Issue:
  11
• NIOSHTIC Number:
  nn:20060755
• Citation:
  Occup Environ Med 2020 Nov; 77(11):790-794
• Contact Point Address:
  Dr A Scott Laney, Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
• Email:
  aol4@cdc.gov
• Federal Fiscal Year:
  2021
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1df236153e5e9e585b4215cd85ce03920b2ba35c84a20ca6dcad92ecf864c21e3e6fa5b1f07e182f8d34fdbd731d85081a256a959674cdb97893f9f5fe617120
• Download URL:
  https://stacks.cdc.gov/view/cdc/224577/cdc_224577_DS1.pdf
• File Type:
  [PDF - 445.08 KB ]