World Trade Center Dust Induces Airway Inflammation While Promoting Aortic Endothelial Dysfunction

Details

• Personal Author:
  Chen LC ; Galdanes K ; Gordon T ; Halzack B ; Harrington A ; Hernandez M ; Lippmann, Morton ; Ma Y ; Sebasco E ; Vaughan J ; Zhong M
• Description:
  Respiratory ailments have plagued occupational and public health communities exposed to World Trade Center (WTC) dust since the September 11, 2001 attack on the Twin Towers in Lower Manhattan. We proposed that these ailments were proposed to be induced by inhalation exposure to WTC particulate matter (WTCPM), that was released during the collapse of the buildings and its subsequent resuspension during cleanup. We investigated this hypothesis using both an in vitro and an in vivo mouse intranasal (IN) exposure models to identify the inflammatory potential of WTCPM with specific emphasis on respiratory and endothelial tissue responses. The in vitro exposure studies found WTCPM exposure to be positively correlated with cytotoxicity and increased NO2- production in both BEAS-2B pulmonary epithelial cells and THP-1 macrophage cells. The in vivo C57BL/6 mouse studies found significant increases in inflammatory markers including increases in polymorphonuclear neutrophil (PMN) influx into nasal and bronchoalveolar lavage fluids (NLF and BALF), as well as increased levels of total protein and cytokine/chemokines levels. Concurrently, NLF, BALF, and serum NO2- levels exhibited significant homeostatic temporal deviations as well as temporal myograohic aortic dysfunction in myography studies. Respiratory exposure to- and evidence -based retention of- WTCPM may have contributed to chronic systemic effects in exposed mice that r resembled to observed effects in WTCPM-exposed human populations. Collectively, these findings are reflective of WTCPM exposure and its effect(s) on respiratory and aortic tissues, highlighting potential dysfunctional pathways that may precipitate inflammatory events, while simultaneously altering homeostatic balances. The tight interplay between these balances, when chronically altered, may contribute to- or result in- chronically diseased pathological states. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Blood Cytotoxins Dust Energy Metabolism Hazardous Substances Immune System Laboratories Lung Lung Diseases Macrophages Nitric Oxide Occupational Health Particulate Matter Pathology Respiratory System Respiratory Tract Diseases Safety September 11 Terrorist Attacks

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• Keywords:
  Airborne Particles Airway Resistance Analytical Models Author Keywords: World Trade Center Dust Cardiovascular System Cell Function Cellular Effects Cellular Reactions Chronic Inflammation Cytotoxicity Dust Exposure Endothelial Cell Dysfunction Histopathology Immune Reaction Inhalation Inhalation Toxicology Intranasal Instillation In Vitro Study In Vivo Study Laboratory Animals Metabolites Muscle Contraction Neutrophils Nitric Oxide Particulate Matter Exposure Particulates Pulmonary Effects Pulmonary Inflammation Pulmonary System Disorders Respiratory System Disorders Tissue Disorders Toxic Effects Toxic Materials World Trade Center WTC

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• ISSN:
  0041-008X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  400
• NIOSHTIC Number:
  nn:20060720
• Citation:
  Toxicol Appl Pharmacol 2020 Aug; 400:115041
• Contact Point Address:
  Lung Chi Chen, Department of Environmental Medicine, New York University School of Medicine, 341 E. 25th St., New York, NY 10010, USA
• Email:
  lcc4@nyu.edu
• CAS Registry Number:
  Nitric oxide (CAS RN 10102-43-9)
• Federal Fiscal Year:
  2020
• Performing Organization:
  New York University School of Medicine
• Peer Reviewed:
  True
• Start Date:
  20160901
• Source Full Name:
  Toxicology and Applied Pharmacology
• End Date:
  20200831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bf24968cf93832a3c200e91043f76dec82f1a9a9bf37f5cd0492d491aee8bfc473478fcbf1051b6123080e1ccaace7b8f2b43b30fb947e4afd5e2fc57fdfa310
• Download URL:
  https://stacks.cdc.gov/view/cdc/224550/cdc_224550_DS1.pdf
• File Type:
  [PDF - 1.37 MB ]